About: Development and use of non-FDG PET radiopharmaceuticals at the Masaryk Memorial Cancer Institute

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About: Development and use of non-FDG PET radiopharmaceuticals at the Masaryk Memorial Cancer Institute Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Positron Emission Tomography (PET) is a convenient method for measurement of aerosol deposition in complex models of lungs. It allows not only the evaluation of regional deposition characteristics but also precisely detects deposition hot spots. The method is based on a detection of a pair of annihilation photons moving in opposite directions as a result of positron - electron interaction after the positron emission decay of a suitable radioisotope. Liquid di(2-ethylhexyl) sebacate (DEHS) particles tagged with fluorine-18 as a radioactive tracer were generated by condensation monodisperse aerosol generator. Aerosol deposition was measured for three different inhalation flowrates and for two sizes of particles. Combination of PET with Computed Tomography (CT) in one device allowed precise localisation of particular segments of the model. The results proved correlation of deposition efficiency with Stokes number, which means that the main deposition mechanism is inertial impaction. As a next task the methodology for tagging the solid aerosol particles with radioactive tracer will be developed and deposition of porous and fiber aerosols will be measured. Positron Emission Tomography (PET) is a convenient method for measurement of aerosol deposition in complex models of lungs. It allows not only the evaluation of regional deposition characteristics but also precisely detects deposition hot spots. The method is based on a detection of a pair of annihilation photons moving in opposite directions as a result of positron - electron interaction after the positron emission decay of a suitable radioisotope. Liquid di(2-ethylhexyl) sebacate (DEHS) particles tagged with fluorine-18 as a radioactive tracer were generated by condensation monodisperse aerosol generator. Aerosol deposition was measured for three different inhalation flowrates and for two sizes of particles. Combination of PET with Computed Tomography (CT) in one device allowed precise localisation of particular segments of the model. The results proved correlation of deposition efficiency with Stokes number, which means that the main deposition mechanism is inertial impaction. As a next task the methodology for tagging the solid aerosol particles with radioactive tracer will be developed and deposition of porous and fiber aerosols will be measured. (en)
Title	Development and use of non-FDG PET radiopharmaceuticals at the Masaryk Memorial Cancer Institute Development and use of non-FDG PET radiopharmaceuticals at the Masaryk Memorial Cancer Institute (en)
skos:prefLabel	Development and use of non-FDG PET radiopharmaceuticals at the Masaryk Memorial Cancer Institute Development and use of non-FDG PET radiopharmaceuticals at the Masaryk Memorial Cancer Institute (en)
skos:notation	RIV/46356088:_____/12:#0001243!RIV13-MPO-46356088
http://linked.open...avai/predkladatel	ÚJV Řež, a. s.
http://linked.open...avai/riv/aktivita	N P
http://linked.open...avai/riv/aktivity	N, P(ED2.1.00/03.0101)
http://linked.open...iv/cisloPeriodika	S2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Adam, Jan Kadeřávek, Jan Kužel, Filip
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	ÚJV Řež, a. s.
http://linked.open...dnocenehoVysledku	130736
http://linked.open...ai/riv/idVysledku	RIV/46356088:_____/12:#0001243
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	positron emission tomgraphy; radiopharmaceuticals; FDG (en)
http://linked.open.../riv/klicoveSlovo	FDG positron emission tomgraphy radiopharmaceuticals
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[1AB016B5E293]
http://linked.open...i/riv/nazevZdroje	Klinická onkologie
http://linked.open...in/vavai/riv/obor	FS
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Regional Centre for Applied Molecular Oncology (RECAMO)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	25
http://linked.open...iv/tvurceVysledku	Adam, Jan Kadeřávek, Jan Kužel, Filip
issn	0862-495X
number of pages	5 (xsd:int)

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