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  • The biological effect of ionizing radiation is mediated practically always by the clusters of radicals formed by densely ionizing track ends of primary or secondary particles. In the case of low-LET radiation the direct effect may be practically neglected and the radical clusters meet a DNA molecule always some time after their formation. The corresponding damage effect (formation of DSB) depends then on the evolution running in individual clusters, being influenced by present chemical agents. Two main parallel processes influence then final effect: diffusion of corresponding radical clusters (lowering radical concentrations) and chemical reactions of all chemical substances present in the clusters. The processes running in the corresponding radical clusters will be modeled with the help of continuous Petri net, which enables us to study the concurrent influence of both the processes: lowering concentration of radicals due diffusion and due chemical reactions. The given model may be helpful especially when the effect of radicals on DSB formation (DNA damage) at the presence of different substances influencing radiobiological effect is to be studied.
  • The biological effect of ionizing radiation is mediated practically always by the clusters of radicals formed by densely ionizing track ends of primary or secondary particles. In the case of low-LET radiation the direct effect may be practically neglected and the radical clusters meet a DNA molecule always some time after their formation. The corresponding damage effect (formation of DSB) depends then on the evolution running in individual clusters, being influenced by present chemical agents. Two main parallel processes influence then final effect: diffusion of corresponding radical clusters (lowering radical concentrations) and chemical reactions of all chemical substances present in the clusters. The processes running in the corresponding radical clusters will be modeled with the help of continuous Petri net, which enables us to study the concurrent influence of both the processes: lowering concentration of radicals due diffusion and due chemical reactions. The given model may be helpful especially when the effect of radicals on DSB formation (DNA damage) at the presence of different substances influencing radiobiological effect is to be studied. (en)
Title
  • Modeling of the chemical stage in water radiolysis using Petri nets
  • Modeling of the chemical stage in water radiolysis using Petri nets (en)
skos:prefLabel
  • Modeling of the chemical stage in water radiolysis using Petri nets
  • Modeling of the chemical stage in water radiolysis using Petri nets (en)
skos:notation
  • RIV/44555601:13440/14:43885830!RIV15-MSM-13440___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 29840
http://linked.open...ai/riv/idVysledku
  • RIV/44555601:13440/14:43885830
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Petri nets; radiolysis; chemical stage; Modeling (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [57E201108922]
http://linked.open...v/mistoKonaniAkce
  • Praha, ČR
http://linked.open...i/riv/mistoVydani
  • Bristol
http://linked.open...i/riv/nazevZdroje
  • Journal of Physics
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Barilla, Jiří
  • Lokajíček, M.
  • Pisaková, H.
  • Simr, Pavel
http://linked.open...vavai/riv/typAkce
http://linked.open...ain/vavai/riv/wos
  • 000335909300198
http://linked.open.../riv/zahajeniAkce
issn
  • 1742-6596
number of pages
http://bibframe.org/vocab/doi
  • 10.1088/1742-6596/490/1/012200
http://purl.org/ne...btex#hasPublisher
  • Institute of Physics Publishing
http://localhost/t...ganizacniJednotka
  • 13440
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