About: Carbosilane cationic dendrimers synthesized by thiol-ene click chemistry and their use as antibacterial agents

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cationic carbosilane dendrimers of generations 1-3 have been synthesized employing thiol-ene click chemistry. The obtained dendrimers present three different types of ammonium functions, two of them with the charge at the surface, -NH3 + and -NMe3 +, and other with the charge internalized by the presence of ethylalcohol moieties, -[NMe2(CH2CH2OH)]+. The influence of -NMe3 + and -[NMe2(CH2CH2OH)]+ in dendrimer structure have been studied by molecular dynamics. The antibacterial properties of these families of dendrimers have been evaluated against Gram-positive (Staphylococcus aureus CECT 240) and Gramnegative (Escherichia coli CECT 515) bacterial strains, and the results have been compared with those obtained for related cationic carbosilane dendrimers functionalized by hydrosilylation reactions. These data show the relevance of the sulfur atom versus the silicon atom close to the dendrimer surface and the outer charge versus the inner charge. Finally, the stability of the most active first generation dendrimers vs. pH and temperature has also been studied. Cationic carbosilane dendrimers of generations 1-3 have been synthesized employing thiol-ene click chemistry. The obtained dendrimers present three different types of ammonium functions, two of them with the charge at the surface, -NH3 + and -NMe3 +, and other with the charge internalized by the presence of ethylalcohol moieties, -[NMe2(CH2CH2OH)]+. The influence of -NMe3 + and -[NMe2(CH2CH2OH)]+ in dendrimer structure have been studied by molecular dynamics. The antibacterial properties of these families of dendrimers have been evaluated against Gram-positive (Staphylococcus aureus CECT 240) and Gramnegative (Escherichia coli CECT 515) bacterial strains, and the results have been compared with those obtained for related cationic carbosilane dendrimers functionalized by hydrosilylation reactions. These data show the relevance of the sulfur atom versus the silicon atom close to the dendrimer surface and the outer charge versus the inner charge. Finally, the stability of the most active first generation dendrimers vs. pH and temperature has also been studied. (en)
Title	Carbosilane cationic dendrimers synthesized by thiol-ene click chemistry and their use as antibacterial agents Carbosilane cationic dendrimers synthesized by thiol-ene click chemistry and their use as antibacterial agents (en)
skos:prefLabel	Carbosilane cationic dendrimers synthesized by thiol-ene click chemistry and their use as antibacterial agents Carbosilane cationic dendrimers synthesized by thiol-ene click chemistry and their use as antibacterial agents (en)
skos:notation	RIV/44555601:13440/14:43885156!RIV15-MSM-13440___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Malý, Marek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Jana Evangelisty Purkyně v Ústí nad Labem / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	6223
http://linked.open...ai/riv/idVysledku	RIV/44555601:13440/14:43885156
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HIV; salts; polymers; efficient; transfection; complexation; ThioEther dendrimers; antimicobial activity; Ammonium; Quaternary (en)
http://linked.open.../riv/klicoveSlovo	polymers salts Ammonium HIV transfection complexation efficient ThioEther dendrimers antimicobial activity Quaternary
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[BAA7A4C1111B]
http://linked.open...i/riv/nazevZdroje	RSC Advances
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	4
http://linked.open...iv/tvurceVysledku	Malý, Marek Sánchez-Nieves, Javier Camero, M. Alejandra Copa-Patino, José Luis Fuentes-Paniagua, Elena Hernández-Ros, José Manuel Juan, Soliveri Pérez-Serrano, Jorge Rafae, Gómez Sánchez-Milla, Maria de la Mata, F. J.
http://linked.open...ain/vavai/riv/wos	000327868400035
issn	2046-2069
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1039/c3ra45408h
http://localhost/t...ganizacniJednotka	13440

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