About: The fluidity changesofneutral and negativelycharged lipid model membranescaused by maltosemodified PPI G5 dendrimers

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About: The fluidity changesofneutral and negativelycharged lipid model membranescaused by maltosemodified PPI G5 dendrimers Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Dendrimers are symmetrically hyperbranched nano-sized polymers presenting vast potential in drug delivery applications. Drugs conjugated with dendrimers are slowly released, accumulate in tumors and have lower toxicity. Despite many advantages dendrimers which possess cationic groups on the surface are very cytotoxic and hemolytic. Because of that the modifications of surface groups are done but they influence on the carriers efficiency. In this work poly (propylene imine) (PPI) dendrimers of generation 5 (G5) with primary amino surface groups were partially (open shell glycodendrimers - OS) or completely (dense shell glycodendrimers - DS) modified with maltose residues. As a model membranes two kinds of 100 nm diameter liposomes were used to research differences in interactions between neutral (DMPC) and negatively charged (DMPC/DMPG) bilayers. Interactions were studied by fluorescence spectroscopy method. In conclusion, both OS and DS PPI G5 dendrimers show interactions with liposomes. The bilayer structure seems more rigid in the case of pure DMPC in comparison of DMPC/DMPG so the interactions with DMPC/DMPG were stronger. For all kinds of experiments presence of NaCl decrease the strength of interactions between dendrimers and liposomes. Resultswerepresented on international konference NANOCON 2013 in Brno (CZ) at 16.-18.10.2013. Dendrimers are symmetrically hyperbranched nano-sized polymers presenting vast potential in drug delivery applications. Drugs conjugated with dendrimers are slowly released, accumulate in tumors and have lower toxicity. Despite many advantages dendrimers which possess cationic groups on the surface are very cytotoxic and hemolytic. Because of that the modifications of surface groups are done but they influence on the carriers efficiency. In this work poly (propylene imine) (PPI) dendrimers of generation 5 (G5) with primary amino surface groups were partially (open shell glycodendrimers - OS) or completely (dense shell glycodendrimers - DS) modified with maltose residues. As a model membranes two kinds of 100 nm diameter liposomes were used to research differences in interactions between neutral (DMPC) and negatively charged (DMPC/DMPG) bilayers. Interactions were studied by fluorescence spectroscopy method. In conclusion, both OS and DS PPI G5 dendrimers show interactions with liposomes. The bilayer structure seems more rigid in the case of pure DMPC in comparison of DMPC/DMPG so the interactions with DMPC/DMPG were stronger. For all kinds of experiments presence of NaCl decrease the strength of interactions between dendrimers and liposomes. Resultswerepresented on international konference NANOCON 2013 in Brno (CZ) at 16.-18.10.2013. (en)
Title	The fluidity changesofneutral and negativelycharged lipid model membranescaused by maltosemodified PPI G5 dendrimers The fluidity changesofneutral and negativelycharged lipid model membranescaused by maltosemodified PPI G5 dendrimers (en)
skos:prefLabel	The fluidity changesofneutral and negativelycharged lipid model membranescaused by maltosemodified PPI G5 dendrimers The fluidity changesofneutral and negativelycharged lipid model membranescaused by maltosemodified PPI G5 dendrimers (en)
skos:notation	RIV/44555601:13440/13:43885742!RIV14-MSM-13440___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(EE2.3.30.0062)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Wróbel, Dominika
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Jana Evangelisty Purkyně v Ústí nad Labem / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	75348
http://linked.open...ai/riv/idVysledku	RIV/44555601:13440/13:43885742
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	dendrimers; PPI; membranescaused; lipid; negativelycharged; fluidity (en)
http://linked.open.../riv/klicoveSlovo	membranescaused negativelycharged PPI dendrimers lipid fluidity
http://linked.open...ontrolniKodProRIV	[BCB2E4761381]
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...vavai/riv/projekt	Chance for young researchers at the University of J. E. Purkyně
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Wróbel, Dominika
http://localhost/t...ganizacniJednotka	13440

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