About: Cationic Carbosilane Dendrimers as Non-virial Vectors of Nucleic Acids (Oligonucleotide or sirNa) for Gene Therapy Purposes

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About: Cationic Carbosilane Dendrimers as Non-virial Vectors of Nucleic Acids (Oligonucleotide or sirNa) for Gene Therapy Purposes Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://rsclive3.rsc.org/publishing/ebooks/2013/9781849736114.asp
Description	A new approach to develop novel non-viral vector for HIV inhibition based on carbosilane dendrimers is described. Cationic ammonium-terminated carbosilane dendrimers have been synthesized via alcoholysis of dendritic Si-Cl bonds or hydrosylilation reactions with dendritic Si-H bonds. Ammonium-terminated carbosilane dendrimers are able to form dendriplexes which showed good biocompatibility profiles in vitro, and protect nucleic acids from binding to serum proteins or RNases and degradation. Finally, they were found to be a successful and efficient vehicle for the transport and delivery of genetic material (ODN or siRNA) to a wide range of immune cells, and according to this, a specific reduction of HIV p24 antigen release by anti-HIV ODN or siRNA was observed. Therefore, the carbosilane dendrimers presented here are in general good candidates as non-viral vectors in the context of biological applications of small nucleic acids, and in particular, they may present a new interesting approach for the treatment of HIV infection. A new approach to develop novel non-viral vector for HIV inhibition based on carbosilane dendrimers is described. Cationic ammonium-terminated carbosilane dendrimers have been synthesized via alcoholysis of dendritic Si-Cl bonds or hydrosylilation reactions with dendritic Si-H bonds. Ammonium-terminated carbosilane dendrimers are able to form dendriplexes which showed good biocompatibility profiles in vitro, and protect nucleic acids from binding to serum proteins or RNases and degradation. Finally, they were found to be a successful and efficient vehicle for the transport and delivery of genetic material (ODN or siRNA) to a wide range of immune cells, and according to this, a specific reduction of HIV p24 antigen release by anti-HIV ODN or siRNA was observed. Therefore, the carbosilane dendrimers presented here are in general good candidates as non-viral vectors in the context of biological applications of small nucleic acids, and in particular, they may present a new interesting approach for the treatment of HIV infection. (en)
Title	Cationic Carbosilane Dendrimers as Non-virial Vectors of Nucleic Acids (Oligonucleotide or sirNa) for Gene Therapy Purposes Cationic Carbosilane Dendrimers as Non-virial Vectors of Nucleic Acids (Oligonucleotide or sirNa) for Gene Therapy Purposes (en)
skos:prefLabel	Cationic Carbosilane Dendrimers as Non-virial Vectors of Nucleic Acids (Oligonucleotide or sirNa) for Gene Therapy Purposes Cationic Carbosilane Dendrimers as Non-virial Vectors of Nucleic Acids (Oligonucleotide or sirNa) for Gene Therapy Purposes (en)
skos:notation	RIV/44555601:13440/13:43885365!RIV14-MSM-13440___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Malý, Jan Malý, Marek
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Jana Evangelisty Purkyně v Ústí nad Labem / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	64420
http://linked.open...ai/riv/idVysledku	RIV/44555601:13440/13:43885365
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Purposes; Therapy; Gene; for; sirNa; Oligonucleotide; Acids; Nucleic; Vectors; Non-virial; Dendrimers; Carbosilane; Cationic (en)
http://linked.open.../riv/klicoveSlovo	Therapy Purposes for Acids Carbosilane Cationic Dendrimers Non-virial Nucleic Oligonucleotide sirNa Gene Vectors
http://linked.open...ontrolniKodProRIV	[C884A19D4FED]
http://linked.open...i/riv/mistoVydani	London
http://linked.open...vEdiceCisloSvazku	1
http://linked.open...i/riv/nazevZdroje	Dendrimers in Biomedical Applications
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...v/pocetStranKnihy	200 (xsd:int)
http://linked.open...cetTvurcuVysledku	13 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Malý, Jan Malý, Marek
number of pages	15 (xsd:int)
http://bibframe.org/vocab/doi	10.1039/9781849737296-00040
http://purl.org/ne...btex#hasPublisher	Royal Society of Chemistry
https://schema.org/isbn	978-1-84973-611-4
http://localhost/t...ganizacniJednotka	13440

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