About: Effects of Oxime K203 and Oxidative Stress in Plasma of Tabun Poisoned Rats

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The highly toxic nature of tabun has been known for many years, but there are still serious limitations to antidotal therapy. In this study, we used rats as an experimental model to evaluate the efficiency of bispyridinium para-oxime 1(203 as therapy against tabun poisoning as well as to examine if induction of oxidative stress is linked to organophosphate toxicity. 1(203 showed high potency in counteracting tabun poisoning. Either alone or in combination with atropine, this oxime significantly increased cholinesterase activity at 0.5 and 1 h compared to untreated rats poisoned with tabun. Simultaneous measurements of markers of oxidative stress (lipid peroxidation and superoxide dismutase) showed that tabun poisoning, but also therapy (oxime alone or oxime plus atropine) applied immediately after tabun poisoning, could generate free radical species that may cause oxidative stress in rats. The highly toxic nature of tabun has been known for many years, but there are still serious limitations to antidotal therapy. In this study, we used rats as an experimental model to evaluate the efficiency of bispyridinium para-oxime 1(203 as therapy against tabun poisoning as well as to examine if induction of oxidative stress is linked to organophosphate toxicity. 1(203 showed high potency in counteracting tabun poisoning. Either alone or in combination with atropine, this oxime significantly increased cholinesterase activity at 0.5 and 1 h compared to untreated rats poisoned with tabun. Simultaneous measurements of markers of oxidative stress (lipid peroxidation and superoxide dismutase) showed that tabun poisoning, but also therapy (oxime alone or oxime plus atropine) applied immediately after tabun poisoning, could generate free radical species that may cause oxidative stress in rats. (en)
Title	Effects of Oxime K203 and Oxidative Stress in Plasma of Tabun Poisoned Rats Effects of Oxime K203 and Oxidative Stress in Plasma of Tabun Poisoned Rats (en)
skos:prefLabel	Effects of Oxime K203 and Oxidative Stress in Plasma of Tabun Poisoned Rats Effects of Oxime K203 and Oxidative Stress in Plasma of Tabun Poisoned Rats (en)
skos:notation	RIV/44555601:13440/12:43884027!RIV13-MSM-13440___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GP305/07/P162)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Kuča, Kamil Musílek, Kamil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Jana Evangelisty Purkyně v Ústí nad Labem / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	133480
http://linked.open...ai/riv/idVysledku	RIV/44555601:13440/12:43884027
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	superoxide dismutase; lipid peroxidation; cholinesterase; K203; therapy; tabun (en)
http://linked.open.../riv/klicoveSlovo	cholinesterase therapy K203 tabun lipid peroxidation superoxide dismutase
http://linked.open...odStatuVydavatele	HR - Chorvatská republika
http://linked.open...ontrolniKodProRIV	[21A55B91C6B4]
http://linked.open...i/riv/nazevZdroje	Croatica Chemica Acta
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Relationship between structure of acetylcholinesterase reactivators and their reactivation potency
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	85
http://linked.open...iv/tvurceVysledku	Kuča, Kamil Musílek, Kamil Berend, Suzana Radič, Bozica Vrdoljak, Ana Lucik
http://linked.open...ain/vavai/riv/wos	000306880200010
issn	0011-1643
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.5562/cca1811
http://localhost/t...ganizacniJednotka	13440
is http://linked.open...avai/riv/vysledek of	Effects of Oxime K203 and Oxidative Stress in Plasma of Tabun Poisoned Rats

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