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| Description
| - Injected, nano-scale drug delivery systems, or nanovectors, are ideal candidates to provide breakthrough solutions to the time-honored problem of optimizing therapeutic index for a treatment. Even modest amounts of progress towards this goal have historically engendered substantial benefits across multiple fields of medicine, with the translability, for example, from oncology to infectious diseases being granted by the fact that the progresses had a single common denominator in the underlying technological platform. In this work we combine multiscale molecular modeling and experimental approaches to define the mode and the molecular requirements of the interaction of oligonucleotide-based therapeutics (e.g., small interfering (si)RNA) and dendrimeric delivery reagents. In details, by mimicking in silico the experiments performed in vitro, information at the molecular level (e.g., interaction forces, mechanisms, structures, free energies of binding, self-assembly, etc.), which cannot be accessed by oth
- Injected, nano-scale drug delivery systems, or nanovectors, are ideal candidates to provide breakthrough solutions to the time-honored problem of optimizing therapeutic index for a treatment. Even modest amounts of progress towards this goal have historically engendered substantial benefits across multiple fields of medicine, with the translability, for example, from oncology to infectious diseases being granted by the fact that the progresses had a single common denominator in the underlying technological platform. In this work we combine multiscale molecular modeling and experimental approaches to define the mode and the molecular requirements of the interaction of oligonucleotide-based therapeutics (e.g., small interfering (si)RNA) and dendrimeric delivery reagents. In details, by mimicking in silico the experiments performed in vitro, information at the molecular level (e.g., interaction forces, mechanisms, structures, free energies of binding, self-assembly, etc.), which cannot be accessed by oth (en)
- Jako vhodné řešení problému cílené a efektivní distribuce léčiv v těle se ukazuje použití transportních nanosystémů. Právě dendrimery jsou svými unikátními vlastnostmi (monodisperzita, velké množství povrchových/terminálních skupin, jež mohou být vhodně modifikovány pro optimální interkci jak s terapeutiky tak s buněčnou stěnou, existence vnitřních ?dutin? v nichž mohou být též transportována různá terapeutika atd.). Tento příspěvek představuje jednak počítačovou studii PAMAM dendrimerů a jejich komplexů s GL3 siRNA na atomární úrovni a jednak mesoškálovou studii různě povrchově modifikovaných dendrimerů. (cs)
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| Title
| - Base Invaders. Coupling Experiments and Multiscale Modeling of Dendrimer-Based siRNA Delivery Agents
- Base Invaders. Coupling Experiments and Multiscale Modeling of Dendrimer-Based siRNA Delivery Agents (en)
- Multiškálové modelování dendrimerů jakožto vhodných kandidátů pro transport siRNA (cs)
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| skos:prefLabel
| - Base Invaders. Coupling Experiments and Multiscale Modeling of Dendrimer-Based siRNA Delivery Agents
- Base Invaders. Coupling Experiments and Multiscale Modeling of Dendrimer-Based siRNA Delivery Agents (en)
- Multiškálové modelování dendrimerů jakožto vhodných kandidátů pro transport siRNA (cs)
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| skos:notation
| - RIV/44555601:13440/08:00004406!RIV09-MSM-13440___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/44555601:13440/08:00004406
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Dendrimers; Multiscale Molecular Modeling; Nanovectors; Self Assembly; siRNA Therapeutics (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Advances in Science and Technology
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...iv/tvurceVysledku
| - Malý, Marek
- Danani, Andrea
- Fermeglia, Maurizio
- Posocco, Paola
- Catapano, Carlo V.
- Fraaije, Johannes G.e.m.
- Handgraaf, Jan-Willem
- Málek, Anastasia
- Pavan, Giovanni Maria
- Pricl, Sabrina
- Scocchi, Giulio
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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