About: Dynamics of Trace Element Concentration During Development and Excitotoxic Cell Death in the Cerebellum of Lurcher Mutant Mice

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We measured time-resolved Zn, Cu and Fe concentrations during the course of excitotoxic cell death in the Lurcher (Lc/+) mutant mouse with neutron activation analysis. In the Lc/+ cerebellum, Fe and Zn but not Cu concentrations were substantially lower than in normal cerebellum before the onset of neurodegeneration; then the concentration of all three metals doubled during excitotoxic Purkinje cell (PC) death, before stabilizing at abnormally high levels at the end of cell death progression. The rise in metal concentrations followed the onset and progression of PC loss after a delay of almost a week. This temporal correlation between neurodegenerative progression and metal concentrations indicates that elevated metal concentrations are the consequence of metabolic overload and glial activation during excitotoxicity rather than the primary cause of PC death. We measured time-resolved Zn, Cu and Fe concentrations during the course of excitotoxic cell death in the Lurcher (Lc/+) mutant mouse with neutron activation analysis. In the Lc/+ cerebellum, Fe and Zn but not Cu concentrations were substantially lower than in normal cerebellum before the onset of neurodegeneration; then the concentration of all three metals doubled during excitotoxic Purkinje cell (PC) death, before stabilizing at abnormally high levels at the end of cell death progression. The rise in metal concentrations followed the onset and progression of PC loss after a delay of almost a week. This temporal correlation between neurodegenerative progression and metal concentrations indicates that elevated metal concentrations are the consequence of metabolic overload and glial activation during excitotoxicity rather than the primary cause of PC death. (en)
Title	Dynamics of Trace Element Concentration During Development and Excitotoxic Cell Death in the Cerebellum of Lurcher Mutant Mice Dynamics of Trace Element Concentration During Development and Excitotoxic Cell Death in the Cerebellum of Lurcher Mutant Mice (en)
skos:prefLabel	Dynamics of Trace Element Concentration During Development and Excitotoxic Cell Death in the Cerebellum of Lurcher Mutant Mice Dynamics of Trace Element Concentration During Development and Excitotoxic Cell Death in the Cerebellum of Lurcher Mutant Mice (en)
skos:notation	RIV/26722445:_____/10:#0000580!RIV11-MSM-26722445
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA309/09/1189), Z(AV0Z10480505), Z(MSM2672244501)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kučera, Jan Kranda, Karel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Centrum výzkumu Řež s.r.o.
http://linked.open...dnocenehoVysledku	311720
http://linked.open...ai/riv/idVysledku	RIV/26722445:_____/10:#0000580
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	apoptosis; copper; excitotoxicity; neurodegeneration; Purkinje cell; zinc (en)
http://linked.open.../riv/klicoveSlovo	Purkinje cell excitotoxicity copper zinc apoptosis neurodegeneration
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[E296DF219CA4]
http://linked.open...i/riv/nazevZdroje	Brain Pathology
http://linked.open...in/vavai/riv/obor	BG
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Elemental analysis of intracellular structures of neurones.
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	19
http://linked.open...iv/tvurceVysledku	Kučera, Jan Kranda, Karel
http://linked.open...ain/vavai/riv/wos	000269575600004
http://linked.open...n/vavai/riv/zamer	Jaderná fyzika a příbuzné obory v základním, aplikovaném a interdisciplinárním výzkumu Basic Research and Oriented Research in Industry and Medicine using Neutron Sources
issn	1015-6305
number of pages	10 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Dynamics of Trace Element Concentration During Development and Excitotoxic Cell Death in the Cerebellum of Lurcher Mutant Mice Dynamics of Trace Element Concentration During Development and Excitotoxic Cell Death in the Cerebellum of Lurcher Mutant Mice Dynamics of Trace Element Concentration During Development and Excitotoxic Cell Death in the Cerebellum of Lurcher Mutant Mice

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