About: EGFR mutations in patients with advanced NSCLC.

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About: EGFR mutations in patients with advanced NSCLC. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Genetic testing for the presence of activating EGFR mutations is an essential part of diagnosis of NSCLC and the results have a major impact on the choice of optimal cancer treatment. Molecular targeted therapy with tyrozine kinase inhibitors that block the activation cascade of epidermal growth factor receptor (EGFR-TKI), is one of the new modalities of treatment of NSCLC with advanced stage. In our study, analysis of patients survival with EGFR-TKI treatment showed significantly better profit from this therapy in patients carrying activating mutations of EGFR. The incidence of activating mutations of EGFR gene in NSCLC in our population and also their increased frequency in patients with adenocarcinoma, women and non-smokers correlated with published data in the literature. Genetic testing for the presence of activating EGFR mutations is an essential part of diagnosis of NSCLC and the results have a major impact on the choice of optimal cancer treatment. Molecular targeted therapy with tyrozine kinase inhibitors that block the activation cascade of epidermal growth factor receptor (EGFR-TKI), is one of the new modalities of treatment of NSCLC with advanced stage. In our study, analysis of patients survival with EGFR-TKI treatment showed significantly better profit from this therapy in patients carrying activating mutations of EGFR. The incidence of activating mutations of EGFR gene in NSCLC in our population and also their increased frequency in patients with adenocarcinoma, women and non-smokers correlated with published data in the literature. (en)
Title	EGFR mutations in patients with advanced NSCLC. EGFR mutations in patients with advanced NSCLC. (en)
skos:prefLabel	EGFR mutations in patients with advanced NSCLC. EGFR mutations in patients with advanced NSCLC. (en)
skos:notation	RIV/26475821:_____/12:#0000136!RIV12-MZ0-26475821
http://linked.open...avai/predkladatel	Genomac International, s.r.o.
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NS9718)
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Minárik, Marek Benešová, Lucie
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Genomac International, s.r.o.
http://linked.open...dnocenehoVysledku	133590
http://linked.open...ai/riv/idVysledku	RIV/26475821:_____/12:#0000136
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	NSCLC; EGFR mutations; advanced stage (en)
http://linked.open.../riv/klicoveSlovo	EGFR mutations advanced stage NSCLC
http://linked.open...ontrolniKodProRIV	[DB3A38D6C01E]
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	New possibilities for application of molecular-diagnostic methods for early detection and proper therapy selection of progressing Non-Small Cell Lung Cancer based on detection and monitoring of hypermethylation of specific genes
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Benšová, Lucie Minárik, Marek

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