About: Preparation and purification of recombinant outer surface protein A (rOspA) of Borrelia burgdorferi sensu stricto and Borrelia afzelii.

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About: Preparation and purification of recombinant outer surface protein A (rOspA) of Borrelia burgdorferi sensu stricto and Borrelia afzelii. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The recombinant Outer surface protein A from Borrelia burgdorferi is a possible immunogn for protection of infected humans and animals against development of Lyme borreliosis, a chronic disease characterised by diverse dermatologic, neurologic, rheumatic, and cardiac manifestations. For several years, research and development have been directed towards a vaccine for the prevention of this disease. Animal studies demonstrate that pre-existing antibodies against Osp of B. burgdorferi can prevent infection and disease caused by this organism. Expresion rOspA in E. coli is described. The aim was to obtain rOspA protein in a purity and quantity desirable for immunisation of experimental animals. The recombinant Outer surface protein A from Borrelia burgdorferi is a possible immunogn for protection of infected humans and animals against development of Lyme borreliosis, a chronic disease characterised by diverse dermatologic, neurologic, rheumatic, and cardiac manifestations. For several years, research and development have been directed towards a vaccine for the prevention of this disease. Animal studies demonstrate that pre-existing antibodies against Osp of B. burgdorferi can prevent infection and disease caused by this organism. Expresion rOspA in E. coli is described. The aim was to obtain rOspA protein in a purity and quantity desirable for immunisation of experimental animals. (en) Rekombinantní outer surface protein A z Borrelia burgdorferi je možným imunogenem pro protekci infikovaných lidí a zvířat proti rozvoji Lymské borreliózy, chronického onemocnění charakterizovaného kožními, neurologickými, revmatickými a srdečními projevy. Po několik let bylo pracováno na vývoji vakcíny pro prevenci tohoto onemocnění. Studie na zvířatech prokázaly, že protilátky proti Osp B. burgdorferi mohou zabránit infekci a onemocnění způsobenému tímto organismem. Je popsána exprese rOspA v E.coli. Cílem bylo získání rOspA proteinu v čistotě a množství vhodném pro imunizaci pokusných zvířat. (cs)
Title	Příprava a purifikace rekombinantního outer surface proteinu A (rOspA) Borrelia burgdorferis sensu stricto a Borrelia afzelii. (cs) Preparation and purification of recombinant outer surface protein A (rOspA) of Borrelia burgdorferi sensu stricto and Borrelia afzelii. Preparation and purification of recombinant outer surface protein A (rOspA) of Borrelia burgdorferi sensu stricto and Borrelia afzelii. (en)
skos:prefLabel	Příprava a purifikace rekombinantního outer surface proteinu A (rOspA) Borrelia burgdorferis sensu stricto a Borrelia afzelii. (cs) Preparation and purification of recombinant outer surface protein A (rOspA) of Borrelia burgdorferi sensu stricto and Borrelia afzelii. Preparation and purification of recombinant outer surface protein A (rOspA) of Borrelia burgdorferi sensu stricto and Borrelia afzelii. (en)
skos:notation	RIV/25304046:_____/05:#0000007!RIV06-MPO-25304046
http://linked.open.../vavai/riv/strany	257-259
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(FD-K3/100)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Vrzal, Vladimír Tuháčková, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Bioveta, a.s.
http://linked.open...dnocenehoVysledku	538176
http://linked.open...ai/riv/idVysledku	RIV/25304046:_____/05:#0000007
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	outer surface protein; OspA; Borrelia burgdorferi; Ni-NTA Agarose; Lyme borreliosis (en)
http://linked.open.../riv/klicoveSlovo	Lyme borreliosis Ni-NTA Agarose OspA Borrelia burgdorferi outer surface protein
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[1525D70CC4C6]
http://linked.open...i/riv/nazevZdroje	Biomedical Papers
http://linked.open...in/vavai/riv/obor	EI
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	*Biotechnological production of antigens of Borrelia burgdorferi sensu lato for preparation of prototype of vaccine against Lyme borreliosis.
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	149
http://linked.open...iv/tvurceVysledku	Raška, Milan Weigl, Evžen Křupka, Michal Vrzal, Vladimír Běláková, Jana Tuháčková, Jana Šebestová, Martina
issn	1213-8118
number of pages	3 (xsd:int)

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