About: Long-term protection against hepatitis B after newborn vaccination: 20-year follow-up

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Objectives: Hepatitis B vaccination in children born to hepatitis B surface antigen positive mothers considerably decreased risk of the vertical transmission. Methods: Combine passive-active immunisation was used in 665 newborns of HBsAg positive mothers in the period 1988-2006 years. Results: Protective anti-HBs level after immunisation was proved in 574 of 620 children (93%). Persistence of protective anti-HBs antibodies was detected in 70%, 40% and 25% children in 5, 10 and 15 years of life. Vertical transmission with chronic HBsAg carrier status was detected in 2 infants. Anti-HBc seroconversion was proven in 10 children from 3 to 15 years of age. Natural boosting with an anti-HBs increase was detected in 38 children. Conclusions: Combined active-passive immunisation of newborns against hepatitis B provides persistent protection up to adolescence despite frequent waning anti-HBs antibodies. Objectives: Hepatitis B vaccination in children born to hepatitis B surface antigen positive mothers considerably decreased risk of the vertical transmission. Methods: Combine passive-active immunisation was used in 665 newborns of HBsAg positive mothers in the period 1988-2006 years. Results: Protective anti-HBs level after immunisation was proved in 574 of 620 children (93%). Persistence of protective anti-HBs antibodies was detected in 70%, 40% and 25% children in 5, 10 and 15 years of life. Vertical transmission with chronic HBsAg carrier status was detected in 2 infants. Anti-HBc seroconversion was proven in 10 children from 3 to 15 years of age. Natural boosting with an anti-HBs increase was detected in 38 children. Conclusions: Combined active-passive immunisation of newborns against hepatitis B provides persistent protection up to adolescence despite frequent waning anti-HBs antibodies. (en)
Title	Long-term protection against hepatitis B after newborn vaccination: 20-year follow-up Long-term protection against hepatitis B after newborn vaccination: 20-year follow-up (en)
skos:prefLabel	Long-term protection against hepatitis B after newborn vaccination: 20-year follow-up Long-term protection against hepatitis B after newborn vaccination: 20-year follow-up (en)
skos:notation	RIV/00843989:_____/10:00101357!RIV11-MZ0-00843989
http://linked.open...avai/riv/aktivita	P V
http://linked.open...avai/riv/aktivity	P(NR9275), V
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Rožnovský, Luděk Hozáková, Lubomíra Zjevíková, Alena Orságová, Irena Kabieszová, Libuše
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Ostrava
http://linked.open...dnocenehoVysledku	268906
http://linked.open...ai/riv/idVysledku	RIV/00843989:_____/10:00101357
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hepatitis B; vaccine; newborn; transmission; antibody waning (en)
http://linked.open.../riv/klicoveSlovo	hepatitis B newborn transmission vaccine antibody waning
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[F3F8B3763B71]
http://linked.open...i/riv/nazevZdroje	Infection
http://linked.open...in/vavai/riv/obor	FN
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Vaccination against hepatitis B in newborns of HBsAg positive mothers - long-term evaluation of protection
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	38
http://linked.open...iv/tvurceVysledku	Hozáková, Lubomíra Rožnovský, Luděk Mrázek, J. Kabieszová, Libuše Kloudová, A. Lochman, I. Orságová, Irena Tvrdík, J. Zjevíková, Alena Plisková, L.
http://linked.open...ain/vavai/riv/wos	000282222200008
issn	0300-8126
number of pages	6 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Long-term protection against hepatitis B after newborn vaccination: 20-year follow-up Long-term protection against hepatitis B after newborn vaccination: 20-year follow-up Long-term protection against hepatitis B after newborn vaccination: 20-year follow-up

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