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Description
  • The objective of this study was to collect data on the effectiveness and tolerability of first-line monotherapy with valproate in subjects with focal epilepsy newly diagnosed. Patients were treated with sustained release sodium valproate. Around 1192 adults and 792 children were included. Seizure control and adverse events were assessed after 6 months. At this time 77% of subjects were seizure free ( 83,7% of children and 72,7% of adults).Adverse events were observed in 10,2% of subjects, leading to treatment modification only for 1,7%.
  • The objective of this study was to collect data on the effectiveness and tolerability of first-line monotherapy with valproate in subjects with focal epilepsy newly diagnosed. Patients were treated with sustained release sodium valproate. Around 1192 adults and 792 children were included. Seizure control and adverse events were assessed after 6 months. At this time 77% of subjects were seizure free ( 83,7% of children and 72,7% of adults).Adverse events were observed in 10,2% of subjects, leading to treatment modification only for 1,7%. (en)
  • Cílem této studie bylo zpracování souboru dat se zaměřením na efektivitu a tolerabilitu monoterapie valproátem jako 1.volba léčby nově diagnostikové ložiskové epilepsie. Pacienti byli léčeni řízeně uvolňovaným sodiumvalproátem. 6 měsíců byla sledovaná kontrola záchvatů a výskyt přídatných účinků. Ve studii bylo 1192 dospělých a 792 dětí. Po této době 90% z nich pokračovalo v medikaci, 77% všech subjektů bylo bez záchvatů (83,7% dětí a 72,7% dospělých).Vedlejší účinky byly u 10,2% subjektů, z toho jen v 1,7% vedly k modifikaci léčby (cs)
Title
  • observational study of first-line valproate monotherapy in focal epilepsy
  • observational study of first-line valproate monotherapy in focal epilepsy (en)
  • Primární monoterapie valproátem v léčbě fokální epilepsie- observační studie. (cs)
skos:prefLabel
  • observational study of first-line valproate monotherapy in focal epilepsy
  • observational study of first-line valproate monotherapy in focal epilepsy (en)
  • Primární monoterapie valproátem v léčbě fokální epilepsie- observační studie. (cs)
skos:notation
  • RIV/00843989:_____/08:00015804!RIV09-MZ0-00843989
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • N
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 355701
http://linked.open...ai/riv/idVysledku
  • RIV/00843989:_____/08:00015804
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • clinical trial; efficacy; focal epilepsy; safety; valproate (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [09E4DEAB6320]
http://linked.open...i/riv/nazevZdroje
  • European Journal of Neurology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 15
http://linked.open...iv/tvurceVysledku
  • Kunčíková, Marie
  • Jędrzejczak, J.
  • Magureanu, S.
http://linked.open...ain/vavai/riv/wos
  • 000251668800016
issn
  • 1351-5101
number of pages
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