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| Description
| - Introduction: The aim of this study was to monitor the changes in haemocoagulation parameters in healthy volunteers after a thrombotripsy with 1-hour transcranial Doppler (TCD) monitoring. Materials and Methods: Ten healthy volunteers (5 males and 5 females; age range, 50 ? 70 years; mean age, 56.1 ? 4.5 years) underwent a 1-hour thrombotripsy of the middle cerebral artery (MCA) using a standard diagnostic transcranial 2 ? 4 MHz probe. Two weeks later the subjects underwent a thrombotripsy of the radial artery, and 4 weeks thereafter a standard 20-minute neurosonologic examination (NSE) was conducted. The following measures of coagulation status were determined before, upon completion, and 24 hours after the thrombotripsy: platelet count, aPTT, prothrombin time, fibrinogen, D-dimers, tPA, FDP, ?-2-antiplasmin (AP), plasminogen, PAI-1 antigen, time of euglobulin clot lysis (ECL), homocysteine, and lipoprotein (a). All adverse events were monitored over a 3 month follow-up period. Result
- Introduction: The aim of this study was to monitor the changes in haemocoagulation parameters in healthy volunteers after a thrombotripsy with 1-hour transcranial Doppler (TCD) monitoring. Materials and Methods: Ten healthy volunteers (5 males and 5 females; age range, 50 ? 70 years; mean age, 56.1 ? 4.5 years) underwent a 1-hour thrombotripsy of the middle cerebral artery (MCA) using a standard diagnostic transcranial 2 ? 4 MHz probe. Two weeks later the subjects underwent a thrombotripsy of the radial artery, and 4 weeks thereafter a standard 20-minute neurosonologic examination (NSE) was conducted. The following measures of coagulation status were determined before, upon completion, and 24 hours after the thrombotripsy: platelet count, aPTT, prothrombin time, fibrinogen, D-dimers, tPA, FDP, ?-2-antiplasmin (AP), plasminogen, PAI-1 antigen, time of euglobulin clot lysis (ECL), homocysteine, and lipoprotein (a). All adverse events were monitored over a 3 month follow-up period. Result (en)
- Cílem studie vylo monitorovat změny v hemokoagulačních parametrech u zdravých dobrovolníků po trombotripsy s 1-hodinovým transkraniálním Dopplerovským monitoringem pomocí 2-4MHz sondy. Materiál a metodika: deset zdravých dobrovolníků podstoupilo 1-hodinovou trombotripsy a. cerebri media (ACM), trombotripsy a. radialis (AR) 20-minutové stndardní ultrazvukové vyšetření (SUV) ve 2-týdenních intervalech. Před zahájením, při ukončení trombotripse či SUV a po 24 hodinách bylo hodnoceno počet krevních destiček, aPTT, alfa-2-antiplastin (AP), plasminogen, PAI-1 antigen, euglobulínová fibrinolýzaIEF, homocystein a lipoprotein. Byly sledovány všechny nežádoucí účinky. Výsledky: po trombotripsy ACM došlo k signifikantnímu snížení PAI-1 antigenu, tPA antigenu, fibrinogenu a AP aktivity o 32,23,7, resp. 4%. Po trombotripsu AR došlo ke snížení jen tPA antigenu a to o 14%. Po SUV nedošlo ke změně ve sledovaných parametrech. Závěr: trombotripsw pomocí 1-hodinového TCD monitoringu s 2-4 MHz diagnostick (cs)
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| Title
| - Changes in haemocoagulation in healthy volunteers after a 1-hour thrombotripsy using a diagnostic 2-4 MHz transcranial probe
- Změny v hemokoagulaci u zdravých dobrovolníků po 1-hodoinové trombotripsy pomocí diagnostické 2-4MHz transkraniální sondy (cs)
- Changes in haemocoagulation in healthy volunteers after a 1-hour thrombotripsy using a diagnostic 2-4 MHz transcranial probe (en)
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| skos:prefLabel
| - Changes in haemocoagulation in healthy volunteers after a 1-hour thrombotripsy using a diagnostic 2-4 MHz transcranial probe
- Změny v hemokoagulaci u zdravých dobrovolníků po 1-hodoinové trombotripsy pomocí diagnostické 2-4MHz transkraniální sondy (cs)
- Changes in haemocoagulation in healthy volunteers after a 1-hour thrombotripsy using a diagnostic 2-4 MHz transcranial probe (en)
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| skos:notation
| - RIV/00843989:_____/08:00014984!RIV09-MZ0-00843989
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00843989:_____/08:00014984
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - ultrasound monitoring; haemocoagulation; fibrinolytic system; transcranial probe (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Journal of thrombosis and thrombolysis
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Blatný, J.
- Zapletalová, Olga
- Školoudík, David
- Fadrná, Táňa
- Penka, M.
- Bar, Michal
- Zapletal, O.
- Langová, K.
- Herzig, R.
- Kaňovský, P.
- Hluštík, P.
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| http://linked.open...ain/vavai/riv/wos
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| issn
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| number of pages
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| is http://linked.open...avai/riv/vysledek
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