About: PML and TRF2 protein expression in hereditary and sporadic colon cancer     Goto   Sponge   NotDistinct   Permalink

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  • The aim of this study was to determine if there is any difference in PML protein expression between tumors with stable microsatellites (MSS) and those with high-frequency microsatellite instability (MSI-H), if PML protein expression might be a prognostic factor and if MSI-H tumors more frequently use alternative lengthening of telomeres measured by the presence of ALT-associated PML bodies. The PML protein was downregulated in approximately 20% of tumors; there was no difference between MSS and MSI-H tumors. PML protein expression does not seem to be a prognostic factor.
  • The aim of this study was to determine if there is any difference in PML protein expression between tumors with stable microsatellites (MSS) and those with high-frequency microsatellite instability (MSI-H), if PML protein expression might be a prognostic factor and if MSI-H tumors more frequently use alternative lengthening of telomeres measured by the presence of ALT-associated PML bodies. The PML protein was downregulated in approximately 20% of tumors; there was no difference between MSS and MSI-H tumors. PML protein expression does not seem to be a prognostic factor. (en)
Title
  • PML and TRF2 protein expression in hereditary and sporadic colon cancer
  • PML and TRF2 protein expression in hereditary and sporadic colon cancer (en)
skos:prefLabel
  • PML and TRF2 protein expression in hereditary and sporadic colon cancer
  • PML and TRF2 protein expression in hereditary and sporadic colon cancer (en)
skos:notation
  • RIV/00843989:_____/07:00014879!RIV12-MZ0-00843989
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NR9092), S, V, Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
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  • 441601
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  • RIV/00843989:_____/07:00014879
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  • PML; TRF2; alternative lengthening of telomeres; hMLH1-gene; hMSH2-gene; microsatellite instability (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • SK - Slovenská republika
http://linked.open...ontrolniKodProRIV
  • [6314B3FD42D1]
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  • Neoplasma
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 54
http://linked.open...iv/tvurceVysledku
  • Bouchal, J.
  • Zapletalová, J.
  • Foretová, L.
  • Kolář, Z.
  • Posolda, Tomáš
  • Čuřík, Romuald
  • Plevová, P.
  • Navrátilová, M.
  • Křepelová, A.
  • Papežová, M.
  • Fiurášková, M.
http://linked.open...ain/vavai/riv/wos
  • 000251196300002
http://linked.open...n/vavai/riv/zamer
issn
  • 0028-2685
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