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| Description
| - Polymorphisms in genes coding for CC chemokine receptors, CCR2 and CCR5, have been studied as genetic markers of coronary artery disease (CAD). Whilst the VI genotype of the CCR2 V64I polymorphism has been implicated in the manifestation of myocardial infarction (MI) in different populations , the data on possible involvement of the CCR5 deletion variant in ethiopathogenesis of coronary atherosclerosis are conflicting . A protective effect of CCR5D32 allele against early MI was reported in Spanish males . However, a recent study from the LURIC (Ludwigshafen Risk and Cardiovascular Health) cohort of male and female German patients with CAD did not show any difference between CCR5D32 frequencies in cases and controls. We have, therefore, decided to replicate the original study in our Czech cohort of male patients with early occurrence of MI.
- Polymorphisms in genes coding for CC chemokine receptors, CCR2 and CCR5, have been studied as genetic markers of coronary artery disease (CAD). Whilst the VI genotype of the CCR2 V64I polymorphism has been implicated in the manifestation of myocardial infarction (MI) in different populations , the data on possible involvement of the CCR5 deletion variant in ethiopathogenesis of coronary atherosclerosis are conflicting . A protective effect of CCR5D32 allele against early MI was reported in Spanish males . However, a recent study from the LURIC (Ludwigshafen Risk and Cardiovascular Health) cohort of male and female German patients with CAD did not show any difference between CCR5D32 frequencies in cases and controls. We have, therefore, decided to replicate the original study in our Czech cohort of male patients with early occurrence of MI. (en)
- Polymorfismy v genech kódujících chemokinové receptory CCR2 a CCR5 byly sledovány jako genetické markery kardiovaskulární choroby. Ve vztahu ke vzniku infarktu myokardu byl nalezen v různých populacích vztah polymorfismu chemokinového receptoru CCR2V64I, data potvrzující vztah delečního polymorfismu CCR5 k etiopatogenezi kardiovaskulární choroby jsou rozporuplná. Ochranný vliv CCR5del32 na vznik časného infarktu myokardu předpokládá u španělských mužů španělská studie. Nicméně, kohortová studie LURIC (Německo), do níž byli zařazeni pacienti – muži i ženy s kardiovaskulárním onemocněním neprokázala rozdíly ve frekvencích CCR5del32 ve srovnání s kontrolním souborem. Proto jsme se rozhodli aplikovat původní studie a závěry na naši českou kohortovou studii, do níž byli zařazeni pacienti – muži s časným vznikem infarktu myokardu. (cs)
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| Title
| - CC chemokine receptor 5 (CCR5) deletion polymorphism does not protect Czech males against early myocardial infarction
- Deleční polymorfismus chemokinového receptoru CCR5 nechrání české muže před časným infarktem myokardu (cs)
- CC chemokine receptor 5 (CCR5) deletion polymorphism does not protect Czech males against early myocardial infarction (en)
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| skos:prefLabel
| - CC chemokine receptor 5 (CCR5) deletion polymorphism does not protect Czech males against early myocardial infarction
- Deleční polymorfismus chemokinového receptoru CCR5 nechrání české muže před časným infarktem myokardu (cs)
- CC chemokine receptor 5 (CCR5) deletion polymorphism does not protect Czech males against early myocardial infarction (en)
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| skos:notation
| - RIV/00843989:_____/05:00100056!RIV09-MZ0-00843989
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00843989:_____/05:00100056
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - association; genotype (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Journal of Internal Medicine
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Čermáková, Zuzana
- Petřek, M.
- Lukl, J.
- Petřková, J.
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| http://linked.open...ain/vavai/riv/wos
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| issn
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| number of pages
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| is http://linked.open...avai/riv/vysledek
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