About: Our first clinical experience with radiosynoviorthesis by means of 166Ho-holmium-boro-macroaggregates     Goto   Sponge   NotDistinct   Permalink

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Description
  • V tomto článku hodnotíme terapeutické a vedlejší efekty aplikace holmium-boro-makroagregátů (HBMA) u radiosynoviorthesy (RSO) kolenou. Hodnotili jsme efektivitu a bezpečnost 166Ho-HBMA v prospektivní klinické studii u pacientů trpících chronickou synovitidou. Prokázali jsem pouze nevýznamný únik radiofarmaka z kloubní dutiny do tříselných mízních uzlin. Šest pacientů mělo mírnou nebo výraznou radiační synovitidu. Možnou příčinou může být poměrně vysoká aplikovaná aktivita. Lze vzít v úvahu její omezení. Terapeutické účinky mohou být přesně hodnoceny po delším časovém intervalu, než jsme měli možnost my (6 až 8 týdnů po RSO). 166Ho-boro-makroagregáty mohou rozšířit škálu klinicky užívaných radiofarmak pro RSO (cs)
  • In this paper, we evaluate the therapeutic and adverse effects of the application of 166-holmium-boro-macroaggregates (HMBA) in radiosynovectomy (RSO) of the knees. We assessed the efficacy and safety of 166Ho-HBMA in a prospective clinical trial in patients suffering from chronic synovitis. We proved only insignificant radiopharmaceutical leakage from the joint cavity to the inguinal lymph nodes. Six patients had early slight or great radiation synovitis. The possible cause could be rather high applicated activity. One can take into consideration its reduction. Therapeutic effects can be precisely evaluated after a longer time interval than was possible for us (6-8 weeks after RSO). 166Ho-boro-macroaggregates can extend the scale of clinically used radiopharmaceuticals for RSO.
  • In this paper, we evaluate the therapeutic and adverse effects of the application of 166-holmium-boro-macroaggregates (HMBA) in radiosynovectomy (RSO) of the knees. We assessed the efficacy and safety of 166Ho-HBMA in a prospective clinical trial in patients suffering from chronic synovitis. We proved only insignificant radiopharmaceutical leakage from the joint cavity to the inguinal lymph nodes. Six patients had early slight or great radiation synovitis. The possible cause could be rather high applicated activity. One can take into consideration its reduction. Therapeutic effects can be precisely evaluated after a longer time interval than was possible for us (6-8 weeks after RSO). 166Ho-boro-macroaggregates can extend the scale of clinically used radiopharmaceuticals for RSO. (en)
Title
  • Our first clinical experience with radiosynoviorthesis by means of 166Ho-holmium-boro-macroaggregates
  • Our first clinical experience with radiosynoviorthesis by means of 166Ho-holmium-boro-macroaggregates (en)
  • Naše první klinické zkušenosti s radiosynoviorthesou pomocí 166Ho-holmium-boro-makroagregátů (cs)
skos:prefLabel
  • Our first clinical experience with radiosynoviorthesis by means of 166Ho-holmium-boro-macroaggregates
  • Our first clinical experience with radiosynoviorthesis by means of 166Ho-holmium-boro-macroaggregates (en)
  • Naše první klinické zkušenosti s radiosynoviorthesou pomocí 166Ho-holmium-boro-makroagregátů (cs)
skos:notation
  • RIV/00843989:_____/05:00012513!RIV09-MZ0-00843989
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • V
http://linked.open...iv/cisloPeriodika
  • No.2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 535161
http://linked.open...ai/riv/idVysledku
  • RIV/00843989:_____/05:00012513
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • radiosynoviorthesis; radiation synovectomy; radionuclide synovectomy; holmium-166; 166Ho-boro-macroaggregates; adverse effects; therapeutic effects; chronic synovitis (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • PL - Polská republika
http://linked.open...ontrolniKodProRIV
  • [F431A54B9010]
http://linked.open...i/riv/nazevZdroje
  • Nuclear Medicine Review
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • Vol.8
http://linked.open...iv/tvurceVysledku
  • Kraft, Otakar
  • Ullmann, Vojtěch
  • Kašpárek, Richard
  • Kropáček, M.
  • Melichar, F.
  • Mirzajevova, M.
issn
  • 1506-9680
number of pages
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