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Description
  • Primary cutaneous posttransplant lymphoproliferative disorders (PTLD) are rare. This retrospective, multicenter study of 35 cases aimed to better describe this entity. Cases were (re)-classified according to the WHO-EORTC or the WHO 2008 classifications of lymphomas. Median interval between first transplantation and diagnosis was 85 months. Fifty-seven percent of patients had a kidney transplant. Twenty-four cases (68,6%) were classified as primary cutaneous T cell lymphoma (CTCL) and 11 (31,4%) as primary cutaneous B cell PTLD. Mycosis fungoides (MF) was the most common (50%) CTCL subtype. Ten (90,9%) cutaneous B cell PTLD cases were classified as EBV-associated B cell lymphoproliferations (including one plasmablastic lymphoma and one lymphomatoid granulomatosis) and one as diffuse large B cell lymphoma, other, that was EBV-negative. Sixteen (45,7%) patients died after a median follow-up of 19.5 months (11 [68,8%] with CTCL [6 of whom had CD30+ lymphoproliferative disorders (LPD)] and 5 [31,2%] with cutaneous B cell PTLD. Median survival times for all patients, CTCL and cutaneous B cell PTLD subgroups were 93, 93 and 112 months, respectively. Survival rates for MF were higher than those for CD30+ LPD. The spectrum of primary CTCL in organ transplant recipients (OTR) is similar to that in the general population. The prognosis of posttransplant primary cutaneous CD30+ LPD is worse than postrtransplant MF and than its counterpart in the immunocompetent population. EBV-associated cutaneous B cell LPD predominates in OTR.
  • Primary cutaneous posttransplant lymphoproliferative disorders (PTLD) are rare. This retrospective, multicenter study of 35 cases aimed to better describe this entity. Cases were (re)-classified according to the WHO-EORTC or the WHO 2008 classifications of lymphomas. Median interval between first transplantation and diagnosis was 85 months. Fifty-seven percent of patients had a kidney transplant. Twenty-four cases (68,6%) were classified as primary cutaneous T cell lymphoma (CTCL) and 11 (31,4%) as primary cutaneous B cell PTLD. Mycosis fungoides (MF) was the most common (50%) CTCL subtype. Ten (90,9%) cutaneous B cell PTLD cases were classified as EBV-associated B cell lymphoproliferations (including one plasmablastic lymphoma and one lymphomatoid granulomatosis) and one as diffuse large B cell lymphoma, other, that was EBV-negative. Sixteen (45,7%) patients died after a median follow-up of 19.5 months (11 [68,8%] with CTCL [6 of whom had CD30+ lymphoproliferative disorders (LPD)] and 5 [31,2%] with cutaneous B cell PTLD. Median survival times for all patients, CTCL and cutaneous B cell PTLD subgroups were 93, 93 and 112 months, respectively. Survival rates for MF were higher than those for CD30+ LPD. The spectrum of primary CTCL in organ transplant recipients (OTR) is similar to that in the general population. The prognosis of posttransplant primary cutaneous CD30+ LPD is worse than postrtransplant MF and than its counterpart in the immunocompetent population. EBV-associated cutaneous B cell LPD predominates in OTR. (en)
Title
  • Primary Cutaneous Posttransplant Lymphoproliferative Disorders in Solid Organ Tranpsplant Recipients: A Multicenter European Case Series
  • Primary Cutaneous Posttransplant Lymphoproliferative Disorders in Solid Organ Tranpsplant Recipients: A Multicenter European Case Series (en)
skos:prefLabel
  • Primary Cutaneous Posttransplant Lymphoproliferative Disorders in Solid Organ Tranpsplant Recipients: A Multicenter European Case Series
  • Primary Cutaneous Posttransplant Lymphoproliferative Disorders in Solid Organ Tranpsplant Recipients: A Multicenter European Case Series (en)
skos:notation
  • RIV/00669806:_____/13:10134351!RIV14-MZ0-00669806
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 8
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 99293
http://linked.open...ai/riv/idVysledku
  • RIV/00669806:_____/13:10134351
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • T cell; skin cancer; posttransplant lymphoproliferative disorder; posttransplant lymphoma; organ transplantation; immunosuppressant therapy; CD30 positive lymphoma; B cell (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DK - Dánské království
http://linked.open...ontrolniKodProRIV
  • [3BBE3D8459B7]
http://linked.open...i/riv/nazevZdroje
  • American Journal of Transplantation
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 13
http://linked.open...iv/tvurceVysledku
  • Cooper, S.
  • del Marmol, V.
  • Cetkovská, Petra
  • Alaibac, M.
  • Ali, I.
  • Barete, S.
  • Bavinck, J. N. Bouwes
  • Durukan, E.
  • Euvrard, S.
  • Ferrándiz, C.
  • Frances, C.
  • Geusau, A.
  • Gülec, A. T.
  • Harwood, C. A.
  • Holfbauer, G. F. L.
  • Kanitakis, J.
  • Kempf, W.
  • Laffitte, E.
  • Lebbé, C.
  • Mork, C.
  • Murphy, G. M.
  • Proby, C. M.
  • Seckin, D.
http://linked.open...ain/vavai/riv/wos
  • 000322330000026
issn
  • 1600-6135
number of pages
http://bibframe.org/vocab/doi
  • 10.1111/ajt.12281
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