About: Asymptomatic abdominal aortic aneurysms show histological signs of progression: A quantitative histochemical analysis

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.karger.com/Article/Pdf/339304
Description	Paper summarizes results of our prospective non-randomized study in the field of quantitative histopathological analysis of the abdominal aortic aneurysms. We evaluated samples of 65 AAA pateints and 55 corresponding thrombi, also 6 normal abdominal aortas. Asymptomatic AAAs had more abundant inflammatory infiltrates, lower amounts of PAI-1, a higher number of tPA-positive elements, a greater concentration of VCAM-1 and MMP-2, and a tendency towards decreased collagen content when compared with symptomatic AAAs. Compared with the aneurysmatic aorta, the normal aorta contained less collagen and more elastin, actin, desmin and PAI-1-positive elements; in addition, it was more vascular. Medium-sized AAAs were the most actin and vimentin rich, and large AAAs were the most vascular. Quantitative microscopy seems to offer a new insight into morphology and pathogenesis of AAA. Our results indicate the rupture-prone nature of the asymptomatic AAAs and support the need for AAA screening programs. Paper summarizes results of our prospective non-randomized study in the field of quantitative histopathological analysis of the abdominal aortic aneurysms. We evaluated samples of 65 AAA pateints and 55 corresponding thrombi, also 6 normal abdominal aortas. Asymptomatic AAAs had more abundant inflammatory infiltrates, lower amounts of PAI-1, a higher number of tPA-positive elements, a greater concentration of VCAM-1 and MMP-2, and a tendency towards decreased collagen content when compared with symptomatic AAAs. Compared with the aneurysmatic aorta, the normal aorta contained less collagen and more elastin, actin, desmin and PAI-1-positive elements; in addition, it was more vascular. Medium-sized AAAs were the most actin and vimentin rich, and large AAAs were the most vascular. Quantitative microscopy seems to offer a new insight into morphology and pathogenesis of AAA. Our results indicate the rupture-prone nature of the asymptomatic AAAs and support the need for AAA screening programs. (en)
Title	Asymptomatic abdominal aortic aneurysms show histological signs of progression: A quantitative histochemical analysis Asymptomatic abdominal aortic aneurysms show histological signs of progression: A quantitative histochemical analysis (en)
skos:prefLabel	Asymptomatic abdominal aortic aneurysms show histological signs of progression: A quantitative histochemical analysis Asymptomatic abdominal aortic aneurysms show histological signs of progression: A quantitative histochemical analysis (en)
skos:notation	RIV/00669806:_____/13:10123169!RIV14-MZ0-00669806
http://linked.open...avai/predkladatel	Fakultní nemocnice Plzeň
http://linked.open...avai/riv/aktivita	P R S Z
http://linked.open...avai/riv/aktivity	P(7E09120), P(ED1.1.00/02.0090), R, S, Z(MSM0021620819)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Houdek, Karel Vrzalová, Jindra Moláček, Jiří Třeška, Vladislav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Plzeň
http://linked.open...dnocenehoVysledku	62398
http://linked.open...ai/riv/idVysledku	RIV/00669806:_____/13:10123169
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	multiplex immunoanalysis; stereology; immunohistochemistry; histology; abdominal aortic aneurysm (en)
http://linked.open.../riv/klicoveSlovo	multiplex immunoanalysis immunohistochemistry histology stereology abdominal aortic aneurysm
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[913E898E3538]
http://linked.open...i/riv/nazevZdroje	Pathobiology : journal of immunopathology, molecular and cellular biology
http://linked.open...in/vavai/riv/obor	EA
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	16 (xsd:int)
http://linked.open...vavai/riv/projekt	Fighting Aneurysmal Disease NTIS - New Technologies for Information Society
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	80
http://linked.open...iv/tvurceVysledku	Houdek, Karel Korabečná, Marie Moláček, Jiří Tonar, Zbyněk Třeška, Vladislav Topolčan, Ondřej Valenta, Jiří Vrzalová, Jindra Pešta, Martin Boudová, Ludmila Witter, Kirsti Kočová, Jitka Křížková, Věra Nedorost, Lukáš Eberlová, Lada Tolinger, Pavel
http://linked.open...ain/vavai/riv/wos	000308125900002
http://linked.open...n/vavai/riv/zamer	Náhrada a podpora funkce některých životně důležitých orgánů
issn	1015-2008
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1159/000339304

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