About: Oral cryotherapy can significantly reduce oral mucositis but not acute GVHD incidence in Flu/Mel conditioning allo-SCT

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About: Oral cryotherapy can significantly reduce oral mucositis but not acute GVHD incidence in Flu/Mel conditioning allo-SCT Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.nature.com/bmt/journal/v47/n5/pdf/bmt2011156a.pdf
Description	Oral cavity cooling (cryotherapy) provided during high-dose melphalan bolus or short-infusion administration contributes to local vasoconstriction, lower blood circulation, lower local cytotoxic drug exposure and significantly reduced oral mucositis (OM) incidence.1-3 OM is a significant posttransplant complication, and together with gut tissue damage and inflammation, caused by conditioning regimens, contributes to the development and pathogenesis of acute GVHD.4-6 The incidence of acute GVHD varies between 28 and 45% in the Flu/Mel-reduced intensity conditioning regimen comprising of fludarabine total dose 125-150mg/m2 and melphalan total dose 140-180mg/m2.1,7-9 We decided to analyze the impact of reduced OMincidence (reduced oral tissue damage) on acute GVHD, and analyzed 142 prospectively observed patients after Flu/Mel (fludarabine 30mg/m2 i.v. once daily for 4 days, melphalan 140mg/m2 i.v. one day before transplantation) allo-SCT performed at our institution from January 2005 to December 2010. Oral cavity cooling (cryotherapy) provided during high-dose melphalan bolus or short-infusion administration contributes to local vasoconstriction, lower blood circulation, lower local cytotoxic drug exposure and significantly reduced oral mucositis (OM) incidence.1-3 OM is a significant posttransplant complication, and together with gut tissue damage and inflammation, caused by conditioning regimens, contributes to the development and pathogenesis of acute GVHD.4-6 The incidence of acute GVHD varies between 28 and 45% in the Flu/Mel-reduced intensity conditioning regimen comprising of fludarabine total dose 125-150mg/m2 and melphalan total dose 140-180mg/m2.1,7-9 We decided to analyze the impact of reduced OMincidence (reduced oral tissue damage) on acute GVHD, and analyzed 142 prospectively observed patients after Flu/Mel (fludarabine 30mg/m2 i.v. once daily for 4 days, melphalan 140mg/m2 i.v. one day before transplantation) allo-SCT performed at our institution from January 2005 to December 2010. (en)
Title	Oral cryotherapy can significantly reduce oral mucositis but not acute GVHD incidence in Flu/Mel conditioning allo-SCT Oral cryotherapy can significantly reduce oral mucositis but not acute GVHD incidence in Flu/Mel conditioning allo-SCT (en)
skos:prefLabel	Oral cryotherapy can significantly reduce oral mucositis but not acute GVHD incidence in Flu/Mel conditioning allo-SCT Oral cryotherapy can significantly reduce oral mucositis but not acute GVHD incidence in Flu/Mel conditioning allo-SCT (en)
skos:notation	RIV/00669806:_____/12:10135327!RIV14-MZ0-00669806
http://linked.open...avai/predkladatel	Fakultní nemocnice Plzeň
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Jungová, Alexandra Koza, Vladimír Vokurka, Samuel Karas, Michal Svoboda, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Plzeň
http://linked.open...dnocenehoVysledku	157039
http://linked.open...ai/riv/idVysledku	RIV/00669806:_____/12:10135327
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	prevention; fludarabine; regimen; melphalan; Stem-cell transplantation (en)
http://linked.open.../riv/klicoveSlovo	melphalan fludarabine prevention regimen Stem-cell transplantation
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D124FEE3A918]
http://linked.open...i/riv/nazevZdroje	Bone Marrow Transplantation
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	47
http://linked.open...iv/tvurceVysledku	Jungová, Alexandra Koza, Vladimír Svoboda, Tomáš Karas, Michal Vokurka, Samuel
http://linked.open...ain/vavai/riv/wos	000303923500021
issn	0268-3369
number of pages	3 (xsd:int)
http://bibframe.org/vocab/doi	10.1038/bmt.2011.156

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