About: High-grade mucinous tubular and spindle cell carcinoma: comparative genomic hybridization study

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S1092913410001437
Description	Mucinous tubular and spindle cell carcinoma (MTSCC) has recently been integrated into the World Health Organization classification. Although MTSCC is generally a low-grade carcinoma, MTSCC with high-grade morphology has been recently reported. We present the first case of high-grade MTSCC with comparative genomic hybridization findings. A 60-year-old Japanese man presented with weight loss and general fatigue. He underwent radical nephrectomy because of the clinical diagnosis of renal cancer. Histologic examination of renal tumor showed findings of high-grade MTSCC. Comparative genomic hybridization analysis showed gain of chromosomes 1q, 7, 16, 19q, and Y and loss of chromosomes 1p, 6p, 8p, 11q (del(11)(q23)), and 13. G-band karyotype showed gain of chromosomes 2, 3, 5, 7, 12, 16, and 20 and loss of chromosome 15. Results of our molecular genetic analysis support the idea that high-grade MTSCC is a real counterpart of low-grade MTSCC. There is no evidence to designate such tumors as unclassified renal cell carcinoma. Mucinous tubular and spindle cell carcinoma (MTSCC) has recently been integrated into the World Health Organization classification. Although MTSCC is generally a low-grade carcinoma, MTSCC with high-grade morphology has been recently reported. We present the first case of high-grade MTSCC with comparative genomic hybridization findings. A 60-year-old Japanese man presented with weight loss and general fatigue. He underwent radical nephrectomy because of the clinical diagnosis of renal cancer. Histologic examination of renal tumor showed findings of high-grade MTSCC. Comparative genomic hybridization analysis showed gain of chromosomes 1q, 7, 16, 19q, and Y and loss of chromosomes 1p, 6p, 8p, 11q (del(11)(q23)), and 13. G-band karyotype showed gain of chromosomes 2, 3, 5, 7, 12, 16, and 20 and loss of chromosome 15. Results of our molecular genetic analysis support the idea that high-grade MTSCC is a real counterpart of low-grade MTSCC. There is no evidence to designate such tumors as unclassified renal cell carcinoma. (en)
Title	High-grade mucinous tubular and spindle cell carcinoma: comparative genomic hybridization study High-grade mucinous tubular and spindle cell carcinoma: comparative genomic hybridization study (en)
skos:prefLabel	High-grade mucinous tubular and spindle cell carcinoma: comparative genomic hybridization study High-grade mucinous tubular and spindle cell carcinoma: comparative genomic hybridization study (en)
skos:notation	RIV/00669806:_____/11:10105755!RIV12-MZ0-00669806
http://linked.open...avai/predkladatel	Fakultní nemocnice Plzeň
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Michal, Michal Hes, Ondřej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Plzeň
http://linked.open...dnocenehoVysledku	202068
http://linked.open...ai/riv/idVysledku	RIV/00669806:_____/11:10105755
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Comparative genomic hybridization; High grade; Mucinous tubular and spindle cell carcinoma; Kidney (en)
http://linked.open.../riv/klicoveSlovo	Comparative genomic hybridization Kidney High grade Mucinous tubular and spindle cell carcinoma
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[76E9A0A19462]
http://linked.open...i/riv/nazevZdroje	Annals of Diagnostic Pathology
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Hes, Ondřej Kuroda, Naoto Lee, Gang-Hong Michal, Michal Shuin, Taro Tamura, Masato Inoue, Keiji Naroda, Takushi Taguchi, Takahiro Tominaga, Akira
http://linked.open...ain/vavai/riv/wos	000297481900018
issn	1092-9134
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.anndiagpath.2010.08.003
is http://linked.open...avai/riv/vysledek of	High-grade mucinous tubular and spindle cell carcinoma: comparative genomic hybridization study High-grade mucinous tubular and spindle cell carcinoma: comparative genomic hybridization study

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