About: Clinical significance of head and neck squamous cell cancer biomarkers

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Head and neck tumors belong among the six leading causes of cancer death worldwide. The predominant type of head and neck tumors consists of squamous cell carcinomas (HNSCC). Early detection of primary tumor and relapse is a key factor for enhancing the survival rate of HNSCC patients, because high rates of cases are recognized at advanced stages. Accordingly, biomarkers suitable for the early detection of HNSCC are sorely needed to improve patient outcomes. HNSCC evolve through a multistep process by the accumulation of genetic and phenotypic changes. Searching for specific biomarkers capable of characterizing each degree is therefore really essential. In this review, genomic and gene expression alterations of HNSCC are summarized and associated with HPV status, clinicopathological conditions, and patient history from the perspective of potential biomarker utilization. The emphasis is placed on non-invasive markers detectable from saliva and blood and clinically relevant studies are mentioned in part Head and neck tumors belong among the six leading causes of cancer death worldwide. The predominant type of head and neck tumors consists of squamous cell carcinomas (HNSCC). Early detection of primary tumor and relapse is a key factor for enhancing the survival rate of HNSCC patients, because high rates of cases are recognized at advanced stages. Accordingly, biomarkers suitable for the early detection of HNSCC are sorely needed to improve patient outcomes. HNSCC evolve through a multistep process by the accumulation of genetic and phenotypic changes. Searching for specific biomarkers capable of characterizing each degree is therefore really essential. In this review, genomic and gene expression alterations of HNSCC are summarized and associated with HPV status, clinicopathological conditions, and patient history from the perspective of potential biomarker utilization. The emphasis is placed on non-invasive markers detectable from saliva and blood and clinically relevant studies are mentioned in part (en)
Title	Clinical significance of head and neck squamous cell cancer biomarkers Clinical significance of head and neck squamous cell cancer biomarkers (en)
skos:prefLabel	Clinical significance of head and neck squamous cell cancer biomarkers Clinical significance of head and neck squamous cell cancer biomarkers (en)
skos:notation	RIV/00216305:26620/14:PU112644!RIV15-MSM-26620___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Raudenská, Martina Gumulec, Jaromír Adam, Vojtěch Masařík, Michal Kizek, René Polanská, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	7536
http://linked.open...ai/riv/idVysledku	RIV/00216305:26620/14:PU112644
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Head and neck cancer Tumor markers Cancer Prognosis Papillomavirus miRNA Saliva (en)
http://linked.open.../riv/klicoveSlovo	Head and neck cancer Tumor markers Cancer Prognosis Papillomavirus miRNA Saliva
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[449E8B3724CA]
http://linked.open...i/riv/nazevZdroje	ORAL ONCOLOGY
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	50
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Gumulec, Jaromír Kizek, René Masařík, Michal Sztalmachová, Markéta Raudenská, Martina Polanská, Hana
issn	1368-8375
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	26620

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