About: Serum and Tissue Zinc in Epithelial Malignancies: A Meta-Analysis     Goto   Sponge   NotDistinct   Permalink

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  • Background and Objectives: Current studies give us inconsistent results regarding the association of neoplasms and zinc(II) serum and tissues concentrations. The results of to-date studies using meta-analysis are summarized in this paper. Methods: Web of Science (Science citation index expanded), PubMed (Medline), Embase and CENTRAL were searched. Articles were reviewed by two evaluators; quality was assessed by Newcastle-Ottawa scale; meta-analysis was performed including meta-regression and publication bias analysis. Results: Analysis was performed on 114 case control, cohort and cross-sectional studies of 22737 participants. Decreased serum zinc level was found in patients with lung (effect size =21.04), head and neck (effect size =21.43), breast (effect size =20.93), liver (effect size =22.29), stomach (effect size =21.59), and prostate (effect size =21.36) cancers; elevation was not proven in any tumor. More specific zinc patterns are evident at tissue level, showing increase in breast cancer tis
  • Background and Objectives: Current studies give us inconsistent results regarding the association of neoplasms and zinc(II) serum and tissues concentrations. The results of to-date studies using meta-analysis are summarized in this paper. Methods: Web of Science (Science citation index expanded), PubMed (Medline), Embase and CENTRAL were searched. Articles were reviewed by two evaluators; quality was assessed by Newcastle-Ottawa scale; meta-analysis was performed including meta-regression and publication bias analysis. Results: Analysis was performed on 114 case control, cohort and cross-sectional studies of 22737 participants. Decreased serum zinc level was found in patients with lung (effect size =21.04), head and neck (effect size =21.43), breast (effect size =20.93), liver (effect size =22.29), stomach (effect size =21.59), and prostate (effect size =21.36) cancers; elevation was not proven in any tumor. More specific zinc patterns are evident at tissue level, showing increase in breast cancer tis (en)
Title
  • Serum and Tissue Zinc in Epithelial Malignancies: A Meta-Analysis
  • Serum and Tissue Zinc in Epithelial Malignancies: A Meta-Analysis (en)
skos:prefLabel
  • Serum and Tissue Zinc in Epithelial Malignancies: A Meta-Analysis
  • Serum and Tissue Zinc in Epithelial Malignancies: A Meta-Analysis (en)
skos:notation
  • RIV/00216305:26620/14:PU109388!RIV15-MSM-26620___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(ED1.1.00/02.0068), S
http://linked.open...iv/cisloPeriodika
  • 6
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  • 44561
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  • RIV/00216305:26620/14:PU109388
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  • Zinc, Epithelial Malignancies, MetaAnalysis (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [EF807CB18E07]
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  • PLOS ONE
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  • 9
http://linked.open...iv/tvurceVysledku
  • Adam, Vojtěch
  • Eckschlager, Tomáš
  • Gumulec, Jaromír
  • Kizek, René
  • Masařík, Michal
  • Provazník, Ivo
issn
  • 1932-6203
number of pages
http://bibframe.org/vocab/doi
  • 10.1371/journal.pone.0099790
http://localhost/t...ganizacniJednotka
  • 26620
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