About: Assays for determination of matrix metalloproteinases and their activity

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Matrix metalloproteinases (MMPs) are involved in many physiological and pathological processes. Due to their ability to cleave and to remodel components of surrounding tissues, MMPs may affect cell migration, differentiation, growth, inflammatory processes, neovascularization, wound healing, apoptosis, the uterine cycle and many other actions within the body, including those needed for tumorigenesis and other diseases. MMPs can therefore be used as potential markers for detecting various cancers, neurodegenerative, and immune and cardiovascular diseases. Numerous MMP assays were developed for clinical and research purposes, but far more attention has been devoted to understanding their biological functions. Due to differences in methodology, results obtained in various laboratory settings are difficult to compare because of the lack of standards and analyticalmethods of validation. Limits of detection of particularmethods used for identifyingMMPs are also disputable. Enzymatic, immunochemical and fluo Matrix metalloproteinases (MMPs) are involved in many physiological and pathological processes. Due to their ability to cleave and to remodel components of surrounding tissues, MMPs may affect cell migration, differentiation, growth, inflammatory processes, neovascularization, wound healing, apoptosis, the uterine cycle and many other actions within the body, including those needed for tumorigenesis and other diseases. MMPs can therefore be used as potential markers for detecting various cancers, neurodegenerative, and immune and cardiovascular diseases. Numerous MMP assays were developed for clinical and research purposes, but far more attention has been devoted to understanding their biological functions. Due to differences in methodology, results obtained in various laboratory settings are difficult to compare because of the lack of standards and analyticalmethods of validation. Limits of detection of particularmethods used for identifyingMMPs are also disputable. Enzymatic, immunochemical and fluo (en)
Title	Assays for determination of matrix metalloproteinases and their activity Assays for determination of matrix metalloproteinases and their activity (en)
skos:prefLabel	Assays for determination of matrix metalloproteinases and their activity Assays for determination of matrix metalloproteinases and their activity (en)
skos:notation	RIV/00216305:26620/11:PU95556!RIV13-AV0-26620___
http://linked.open...avai/predkladatel	Středoevropský technologický institut
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(GAP301/10/0356), P(IAA401990701), P(KAN208130801), P(NS10200)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Křížková, Soňa Adam, Vojtěch Masařík, Michal Kizek, René
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	187213
http://linked.open...ai/riv/idVysledku	RIV/00216305:26620/11:PU95556
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	matalloproteinase, pathological process (en)
http://linked.open.../riv/klicoveSlovo	matalloproteinase pathological process
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[87CD547846B5]
http://linked.open...i/riv/nazevZdroje	TRAC-TRENDS IN ANALYTICAL CHEMISTRY
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology Study of contribution of different DNA-damaging mechanisms to toxicity of cytostatics to human chemosensitive and chemoresistant neuroblastomas Study of binding of platinum cytostatics to DNA structure; Influence of metallothionein New design and exploiting nanobiosensors and nanosensors to target medicine (NANOSEMED) Tumor markers, their determination and correlation with prostate carcinoma
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	2011 (30)
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Eckschlager, Tomáš Grace, Chavis J. Kizek, René Křížková, Soňa Masařík, Michal Stiborová, Marie Zítka, Ondřej
issn	0165-9936
number of pages	14 (xsd:int)
http://localhost/t...ganizacniJednotka	26620
is http://linked.open...avai/riv/vysledek of	Assays for determination of matrix metalloproteinases and their activity

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