About: Insight to Physiology and Pathology of Zinc(II) Ions and Their Actions in Breast and Prostate Carcinoma

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	MT protects cells against oxidative stress, because it cooperates with reduced glutathione (GSH). Recent studies indicate elevated serum level of MT in a number of malignancies, among others in breast, and prostate. MT together with zinc(II) affect apoptosis and proliferation, thus together with its antioxidative effects it may affect cancer. To date, only little is known about the influence of zinc(II) and MT on cancer, while these compounds may play an important role in pathogenesis. This review concludes current data regarding the impact of zinc(II) on the pathogenesis of breast and prostate cancers with potential outlines of new, targeted therapy and prevention. Moreover, blood plasma zinc(II) and MT levels and dietary zinc(II) intake are discussed in relation to breast and prostate cancer risk. MT protects cells against oxidative stress, because it cooperates with reduced glutathione (GSH). Recent studies indicate elevated serum level of MT in a number of malignancies, among others in breast, and prostate. MT together with zinc(II) affect apoptosis and proliferation, thus together with its antioxidative effects it may affect cancer. To date, only little is known about the influence of zinc(II) and MT on cancer, while these compounds may play an important role in pathogenesis. This review concludes current data regarding the impact of zinc(II) on the pathogenesis of breast and prostate cancers with potential outlines of new, targeted therapy and prevention. Moreover, blood plasma zinc(II) and MT levels and dietary zinc(II) intake are discussed in relation to breast and prostate cancer risk. (en)
Title	Insight to Physiology and Pathology of Zinc(II) Ions and Their Actions in Breast and Prostate Carcinoma Insight to Physiology and Pathology of Zinc(II) Ions and Their Actions in Breast and Prostate Carcinoma (en)
skos:prefLabel	Insight to Physiology and Pathology of Zinc(II) Ions and Their Actions in Breast and Prostate Carcinoma Insight to Physiology and Pathology of Zinc(II) Ions and Their Actions in Breast and Prostate Carcinoma (en)
skos:notation	RIV/00216305:26620/11:PU95053!RIV13-AV0-26620___
http://linked.open...avai/predkladatel	Středoevropský technologický institut
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(GP301/09/P436), P(KAN208130801), P(NS10200)
http://linked.open...iv/cisloPeriodika	33
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Adam, Vojtěch Masařík, Michal Hubálek, Jaromír Kizek, René
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	205024
http://linked.open...ai/riv/idVysledku	RIV/00216305:26620/11:PU95053
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Zinc, Cancer, Prostate Carcinoma, Breast Carcinoma, Homeostasis, Low Molecular Mass Thiols, Metallothionein, Glutathione, Zinc Intake, Apoptosis, ZnT and ZIP transporters (en)
http://linked.open.../riv/klicoveSlovo	Cancer Metallothionein Zinc Breast Carcinoma Homeostasis Low Molecular Mass Thiols Prostate Carcinoma Zinc Intake ZnT and ZIP transporters Apoptosis Glutathione
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[381928458DFB]
http://linked.open...i/riv/nazevZdroje	CURRENT MEDICINAL CHEMISTRY
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology Metallothionein analysis in prostate carcinoma at DNA, RNA and protein level. New design and exploiting nanobiosensors and nanosensors to target medicine (NANOSEMED) Tumor markers, their determination and correlation with prostate carcinoma
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	2011 (18)
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Gumulec, Jaromír Hubálek, Jaromír Kizek, René Křížková, Soňa Masařík, Michal
http://linked.open...ain/vavai/riv/wos	000299031000003
issn	0929-8673
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	26620
is http://linked.open...avai/riv/vysledek of	Insight to Physiology and Pathology of Zinc(II) Ions and Their Actions in Breast and Prostate Carcinoma

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