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  • Alkaloids, which are known as secondary metabolites, are produced by a large variety of organisms, including plants, fungi, bacteria and animals. Alkaloids are not crucial for the survival of the mentioned organisms, but for their protection. They are grouped by typical structural characteristics into large families such as pyrrolizidine alkaloids (PAs) comprising more than 350 individual heterocyclic compounds. As other alkaloids PAs can cause severe human and animal health problems. Intoxications caused by PAs are described by hepatotoxicity with tendency to hemorrhagic necrosis and veno-occlusion in liver, pneumotoxicity, carcinogenity, mutagenity, and genotoxicity [1]. Thus, there is a need for methods that allow to determinate these dangerous plant toxins. In this study, fast, reliable and sensitive approach is proposed allowing simultaneous screening, identification and quantification of PAs in feed samples. Selected PAs representatives, namely monocrotaline, senkirkine, senecionine, seneciphy
  • Alkaloids, which are known as secondary metabolites, are produced by a large variety of organisms, including plants, fungi, bacteria and animals. Alkaloids are not crucial for the survival of the mentioned organisms, but for their protection. They are grouped by typical structural characteristics into large families such as pyrrolizidine alkaloids (PAs) comprising more than 350 individual heterocyclic compounds. As other alkaloids PAs can cause severe human and animal health problems. Intoxications caused by PAs are described by hepatotoxicity with tendency to hemorrhagic necrosis and veno-occlusion in liver, pneumotoxicity, carcinogenity, mutagenity, and genotoxicity [1]. Thus, there is a need for methods that allow to determinate these dangerous plant toxins. In this study, fast, reliable and sensitive approach is proposed allowing simultaneous screening, identification and quantification of PAs in feed samples. Selected PAs representatives, namely monocrotaline, senkirkine, senecionine, seneciphy (en)
Title
  • Determination of Selected Naturally Occurring Alkaloids in Feed by UPLC-MS/MS
  • Determination of Selected Naturally Occurring Alkaloids in Feed by UPLC-MS/MS (en)
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  • Determination of Selected Naturally Occurring Alkaloids in Feed by UPLC-MS/MS
  • Determination of Selected Naturally Occurring Alkaloids in Feed by UPLC-MS/MS (en)
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  • RIV/00216305:26310/13:PU106499!RIV14-MSM-26310___
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  • 68927
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  • RIV/00216305:26310/13:PU106499
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  • ergot alkaloids, pyrrolizidine alkaloids, chromatography, mass spectrometry (en)
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  • [8528231EEE25]
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  • Brno
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  • Brno
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  • Studentská odborná konference Chemie je život 2013 Studentská odborná konference Chemie je život 2013.Sborník příspěvků.
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  • Čáslavský, Josef
  • Bolechová, Martina
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  • Vysoké učení technické v Brně, Fakulta chemická,
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  • 978-80-214-4823-0
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  • 26310
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