About: Chiral Analysis of the Nonsteroidal Anti-inflammatory Drug Residuals in the Wastewater

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Chiral pharmaceuticals are known to exhibit stereoselective behaviour when situated in a biological system (e.g. living organism) resulting in enantiomers of these compounds showing different biological properties such as toxicity. For better understanding of the fate of chiral pharmaceuticals in the environment it is of great importance to develop chiral analytical methods capable of trace analysis in the environmental matrices. Enantioselective HPLC-DAD method was developed for the analysis of two non-steroidal anti-inflammatory drugs: ibuprofen and ketoprofen. Enantiomers of these compounds were separated using Chiralpak AD as a chiral column in the normal phase mode. Extracted samples of raw and treated wastewater were at first analysed by achiral HPLC-ESI-MS method, which was used for quantification of the sum of ibuprofen and ketoprofen enantiomers. After this, the samples were analyzed by chiral HPLC using diode array detector. It was found out that the diode array detector is not sensitive an Chiral pharmaceuticals are known to exhibit stereoselective behaviour when situated in a biological system (e.g. living organism) resulting in enantiomers of these compounds showing different biological properties such as toxicity. For better understanding of the fate of chiral pharmaceuticals in the environment it is of great importance to develop chiral analytical methods capable of trace analysis in the environmental matrices. Enantioselective HPLC-DAD method was developed for the analysis of two non-steroidal anti-inflammatory drugs: ibuprofen and ketoprofen. Enantiomers of these compounds were separated using Chiralpak AD as a chiral column in the normal phase mode. Extracted samples of raw and treated wastewater were at first analysed by achiral HPLC-ESI-MS method, which was used for quantification of the sum of ibuprofen and ketoprofen enantiomers. After this, the samples were analyzed by chiral HPLC using diode array detector. It was found out that the diode array detector is not sensitive an (en)
Title	Chiral Analysis of the Nonsteroidal Anti-inflammatory Drug Residuals in the Wastewater Chiral Analysis of the Nonsteroidal Anti-inflammatory Drug Residuals in the Wastewater (en)
skos:prefLabel	Chiral Analysis of the Nonsteroidal Anti-inflammatory Drug Residuals in the Wastewater Chiral Analysis of the Nonsteroidal Anti-inflammatory Drug Residuals in the Wastewater (en)
skos:notation	RIV/00216305:26310/12:PU99098!RIV13-MSM-26310___
http://linked.open...avai/predkladatel	Fakulta chemická
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Čáslavský, Josef Svobodová, Dagmar
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Fakulta chemická
http://linked.open...dnocenehoVysledku	126997
http://linked.open...ai/riv/idVysledku	RIV/00216305:26310/12:PU99098
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	chirality, chiral pharmaceuticals, wastewater, HPLC, ibuprofen, ketoprofen, chiralpak AD (en)
http://linked.open.../riv/klicoveSlovo	ibuprofen wastewater HPLC ketoprofen chiralpak AD chiral pharmaceuticals chirality
http://linked.open...ontrolniKodProRIV	[701536627018]
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Svobodová, Dagmar Čáslavský, Josef
http://localhost/t...ganizacniJednotka	26310

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