About: Integration System for Functional Annotation of Single Nucleotide Polymorphism

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This paper describes a new integrative system for ranking non-synonymous protein substitutions by their deleterious effects. The computational core of the proposed system is based on a sophisticated combination of results from the selected subset of existing tools. The weight coefficients for individual tools are calculated on the basis of their confidence score and the tool reliability which are assigned accordingly to the tool performance measured on the extensive dataset. The performance validation on the dataset consisting of 5000 substitutions shows that overall accuracy of the system was improved by 8% in comparison to the best of the integrated methods. This paper describes a new integrative system for ranking non-synonymous protein substitutions by their deleterious effects. The computational core of the proposed system is based on a sophisticated combination of results from the selected subset of existing tools. The weight coefficients for individual tools are calculated on the basis of their confidence score and the tool reliability which are assigned accordingly to the tool performance measured on the extensive dataset. The performance validation on the dataset consisting of 5000 substitutions shows that overall accuracy of the system was improved by 8% in comparison to the best of the integrated methods. (en)
Title	Integration System for Functional Annotation of Single Nucleotide Polymorphism Integration System for Functional Annotation of Single Nucleotide Polymorphism (en)
skos:prefLabel	Integration System for Functional Annotation of Single Nucleotide Polymorphism Integration System for Functional Annotation of Single Nucleotide Polymorphism (en)
skos:notation	RIV/00216305:26230/12:PU101764!RIV13-MSM-26230___
http://linked.open...avai/predkladatel	Fakulta informačních technologií
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0070), S, Z(MSM0021630528)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Zendulka, Jaroslav Bendl, Jaroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Fakulta informačních technologií
http://linked.open...dnocenehoVysledku	142130
http://linked.open...ai/riv/idVysledku	RIV/00216305:26230/12:PU101764
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	SNP, nsSNP, pathogenicity prediction, protein substitutions (en)
http://linked.open.../riv/klicoveSlovo	SNP nsSNP pathogenicity prediction protein substitutions
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[0E6F71687713]
http://linked.open...i/riv/nazevZdroje	ElectroScope - http://www.electroscope.zcu.cz
http://linked.open...in/vavai/riv/obor	IN
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	IT4Innovations Centre of Excellence
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	2012
http://linked.open...iv/tvurceVysledku	Zendulka, Jaroslav Bendl, Jaroslav
http://linked.open...n/vavai/riv/zamer	Výzkum informačních technologií z hlediska bezpečnosti
issn	1802-4564
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	26230
is http://linked.open...avai/riv/vysledek of	Integration System for Functional Annotation of Single Nucleotide Polymorphism

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