About: The Precision of DCE-MRI Using the Tissue Homogeneity Model with Continuous Formulation of the Perfusion Parameters

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The present trend in dynamic contrast-Enhanced MRI is to increase the number of estimated perfusion parameters using complex pharmacokinetic models. However, less attention is given to the precision analysis of the parameter estimates. In this paper, the distributed capillary adiabatic tissue homogeneity pharmacokinetic model is extended by the bolus arrival time formulated as a free continuous parameter. With the continuous formulation of all perfusion parameters, it is possible to use standard gradient-based optimization algorithms in the approximation of the tissue concentration time sequences. This new six-parameter model is investigated by comparing Monte-Carlo simulations with theoretically derived covariance matrices. The covariance-matrix approach is extended from the usual analysis of the primary perfusion parameters of the pharmacokinetic model to the analysis of the perfusion parameters derived from the primary ones. The results indicate that the precision of the estimated perfusion paramet The present trend in dynamic contrast-Enhanced MRI is to increase the number of estimated perfusion parameters using complex pharmacokinetic models. However, less attention is given to the precision analysis of the parameter estimates. In this paper, the distributed capillary adiabatic tissue homogeneity pharmacokinetic model is extended by the bolus arrival time formulated as a free continuous parameter. With the continuous formulation of all perfusion parameters, it is possible to use standard gradient-based optimization algorithms in the approximation of the tissue concentration time sequences. This new six-parameter model is investigated by comparing Monte-Carlo simulations with theoretically derived covariance matrices. The covariance-matrix approach is extended from the usual analysis of the primary perfusion parameters of the pharmacokinetic model to the analysis of the perfusion parameters derived from the primary ones. The results indicate that the precision of the estimated perfusion paramet (en)
Title	The Precision of DCE-MRI Using the Tissue Homogeneity Model with Continuous Formulation of the Perfusion Parameters The Precision of DCE-MRI Using the Tissue Homogeneity Model with Continuous Formulation of the Perfusion Parameters (en)
skos:prefLabel	The Precision of DCE-MRI Using the Tissue Homogeneity Model with Continuous Formulation of the Perfusion Parameters The Precision of DCE-MRI Using the Tissue Homogeneity Model with Continuous Formulation of the Perfusion Parameters (en)
skos:notation	RIV/00216305:26220/14:PU107765!RIV15-MSM-26220___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(ED0017/01/01), P(GAP102/12/2380), P(LO1212), S
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Bartoš, Michal Kratochvíla, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Fakulta elektrotechniky a komunikačních technologií
http://linked.open...dnocenehoVysledku	38697
http://linked.open...ai/riv/idVysledku	RIV/00216305:26220/14:PU107765
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Dynamic contrast-enhanced MRI (DCE-MRI), perfusion, parameter estimation, bolus arrival time (en)
http://linked.open.../riv/klicoveSlovo	perfusion parameter estimation Dynamic contrast-enhanced MRI (DCE-MRI) bolus arrival time
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[9A7295D3DC2C]
http://linked.open...i/riv/nazevZdroje	MAGNETIC RESONANCE IMAGING
http://linked.open...in/vavai/riv/obor	JA
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	ALISI - Centre of advanced diagnostic methods and technologies APPLICATION LABORATORIES OF ADVANCED MICROTECHNOLOGIES AND NANOTECHNOLOGIES Perfusion Analysis Using MRI and Ultrasound
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Bartoš, Michal Jiřík, Radovan Taxt, Torfinn Kratochvíla, Jiří Standara, Michal Starčuk, Zenon
http://linked.open...ain/vavai/riv/wos	000335422800015
issn	0730-725X
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.mri.2014.02.003
http://localhost/t...ganizacniJednotka	26220

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