About: Chip gel electrophoresis as a tool for study of matrix metalloproteinase 9 interaction with metallothionein

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Matrix metalloproteinases (MMPs) play numerous roles in physiological and pathological processes including cancer. Interactions of MMPs with other zinc-binding proteins are of great interest mainly from the point of view of the participation of these proteins in carcinogenesis. The aim of this study was to utilize chip gel electrophoresis for investigation of matrix metalloproteinase 9 (gelatinase B, MMP-9) interactions with collagen. The interaction was observed and the effect of temperature was tested. We further focused on the study of activation of MMP-9 by the presence of zinc-binding proteins called metallothioneins (MT). We confirmed the basic presumption of the activation of MMP-9 by the presence of MT similar to the temperature effect. Moreover, we chose the method of differential pulse voltammetry Brdicka reaction to verify our results. It can be concluded that the activity of MMP-9 was higher in the presence of MT in comparison with the experimental collagen(type I)-MMP-9 mixture in vitro. Matrix metalloproteinases (MMPs) play numerous roles in physiological and pathological processes including cancer. Interactions of MMPs with other zinc-binding proteins are of great interest mainly from the point of view of the participation of these proteins in carcinogenesis. The aim of this study was to utilize chip gel electrophoresis for investigation of matrix metalloproteinase 9 (gelatinase B, MMP-9) interactions with collagen. The interaction was observed and the effect of temperature was tested. We further focused on the study of activation of MMP-9 by the presence of zinc-binding proteins called metallothioneins (MT). We confirmed the basic presumption of the activation of MMP-9 by the presence of MT similar to the temperature effect. Moreover, we chose the method of differential pulse voltammetry Brdicka reaction to verify our results. It can be concluded that the activity of MMP-9 was higher in the presence of MT in comparison with the experimental collagen(type I)-MMP-9 mixture in vitro. (en)
Title	Chip gel electrophoresis as a tool for study of matrix metalloproteinase 9 interaction with metallothionein Chip gel electrophoresis as a tool for study of matrix metalloproteinase 9 interaction with metallothionein (en)
skos:prefLabel	Chip gel electrophoresis as a tool for study of matrix metalloproteinase 9 interaction with metallothionein Chip gel electrophoresis as a tool for study of matrix metalloproteinase 9 interaction with metallothionein (en)
skos:notation	RIV/00216305:26220/11:PU94853!RIV13-AV0-26220___
http://linked.open...avai/predkladatel	Fakulta elektrotechniky a komunikačních technologií
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(IAA401990701), P(KAN208130801)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Adam, Vojtěch Hubálek, Jaromír Kizek, René
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Fakulta elektrotechniky a komunikačních technologií
http://linked.open...dnocenehoVysledku	190192
http://linked.open...ai/riv/idVysledku	RIV/00216305:26220/11:PU94853
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	matrix metalloproteinases, carcinogenesis, cancer (en)
http://linked.open.../riv/klicoveSlovo	cancer carcinogenesis matrix metalloproteinases
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[6C4EB0BDE22A]
http://linked.open...i/riv/nazevZdroje	Electrophoresis
http://linked.open...in/vavai/riv/obor	CG
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of binding of platinum cytostatics to DNA structure; Influence of metallothionein New design and exploiting nanobiosensors and nanosensors to target medicine (NANOSEMED)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	2011 (32)
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Hubálek, Jaromír Húska, Dalibor Kizek, René Křížková, Soňa Zítka, Ondřej
issn	0173-0835
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	26220
is http://linked.open...avai/riv/vysledek of	Chip gel electrophoresis as a tool for study of matrix metalloproteinase 9 interaction with metallothionein

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