About: Modelling the cardiac transverse-axial tubular system

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The transverse-axial tubular system (TATS) of cardiac ventricular myocytes is a complex network of tubules that arises as invaginations of the surface membrane; it appears to form a specialised region of cell membrane that is particularly important for excitation-contraction coupling. However much remains unknown about the structure and role of the TATS. In this brief review we use experimental data and computer modelling to address the following key questions: (i) What fraction of the cell membrane is within the TATS? (ii) Is the composition of the TATS membrane the same as the surface membrane? (iii) How good is electrical coupling between the surface and TATS membranes? (iv) What fraction of each current is within the TATS? (v) How important is the complex structure of the TATS network? (vi) What is the effect of current inhomogeneity on lumenal ion concentrations? (vii) Does the TATS contribute to the functional changes observed in heart failure? Although there are many areas in which experimental The transverse-axial tubular system (TATS) of cardiac ventricular myocytes is a complex network of tubules that arises as invaginations of the surface membrane; it appears to form a specialised region of cell membrane that is particularly important for excitation-contraction coupling. However much remains unknown about the structure and role of the TATS. In this brief review we use experimental data and computer modelling to address the following key questions: (i) What fraction of the cell membrane is within the TATS? (ii) Is the composition of the TATS membrane the same as the surface membrane? (iii) How good is electrical coupling between the surface and TATS membranes? (iv) What fraction of each current is within the TATS? (v) How important is the complex structure of the TATS network? (vi) What is the effect of current inhomogeneity on lumenal ion concentrations? (vii) Does the TATS contribute to the functional changes observed in heart failure? Although there are many areas in which experimental (en)
Title	Modelling the cardiac transverse-axial tubular system Modelling the cardiac transverse-axial tubular system (en)
skos:prefLabel	Modelling the cardiac transverse-axial tubular system Modelling the cardiac transverse-axial tubular system (en)
skos:notation	RIV/00216305:26220/08:PU71089!RIV10-MSM-26220___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z20760514), Z(MSM0021622402), Z(MSM0021630513)
http://linked.open...iv/cisloPeriodika	1-3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Šimurda, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Fakulta elektrotechniky a komunikačních technologií
http://linked.open...dnocenehoVysledku	380001
http://linked.open...ai/riv/idVysledku	RIV/00216305:26220/08:PU71089
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	t-tubules, TATS, Heart, Calcium, Ventricle, Computer model (en)
http://linked.open.../riv/klicoveSlovo	Computer model Calcium Heart t-tubules TATS Ventricle
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[30907CF4F5C8]
http://linked.open...i/riv/nazevZdroje	PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	2008 (96)
http://linked.open...iv/tvurceVysledku	Pásek, Michal Šimurda, Jiří
http://linked.open...n/vavai/riv/zamer	Complex dynamical systems in thermodynamics, fluid and solid mechanics Early diagnostics and treatment of cardiovascular diseases Advanced Electronic Communication Systems and Technologies (ELCOM)
issn	0079-6107
number of pages	18 (xsd:int)
http://localhost/t...ganizacniJednotka	26220
is http://linked.open...avai/riv/vysledek of	Modelling the cardiac transverse-axial tubular system Modelling the cardiac transverse-axial tubular system Modelling the cardiac transverse-axial tubular system Modelling the cardiac transverse-axial tubular system

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