About: A monitorong of allantoin, uric acid, and malondialdehyde levels in plasma and erythrocytes after ten minutes of running activity

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Uric acid is the final product of human purine metabolism. It was pointed out that this compound acts as an antioxidant and is able to react with reactive oxygen species forming allantoin. Therefore, the measurement of allantoin levels may be used for the determination of oxidative stress in humans. The aim of the study was to clarify the antioxidant effect of uric acid during intense exercise. Whole blood samples were obtained from a group of healthy subjects. Allantoin, uric acid, and malondialdehyde levels in plasma and erythrocytes were measured using a HPLC with UV/Vis detection. Statistical significant differences in allantoin and uric acid levels during short-term intense exercise were found. Immediately after intense exercise, the plasma allantoin levels increased on the average of 200 % in comparison to baseline. Plasma uric acid levels increased slowly, at an average of 20 %. On the other hand, there were no significant changes in plasma malondialdehyde. The results suggest that uric acid, important antioxidant, is probably oxidized by reactive oxygen species to allantoin. Therefore allantoin may be suitable candidate for a marker of acute oxidative stress. Uric acid is the final product of human purine metabolism. It was pointed out that this compound acts as an antioxidant and is able to react with reactive oxygen species forming allantoin. Therefore, the measurement of allantoin levels may be used for the determination of oxidative stress in humans. The aim of the study was to clarify the antioxidant effect of uric acid during intense exercise. Whole blood samples were obtained from a group of healthy subjects. Allantoin, uric acid, and malondialdehyde levels in plasma and erythrocytes were measured using a HPLC with UV/Vis detection. Statistical significant differences in allantoin and uric acid levels during short-term intense exercise were found. Immediately after intense exercise, the plasma allantoin levels increased on the average of 200 % in comparison to baseline. Plasma uric acid levels increased slowly, at an average of 20 %. On the other hand, there were no significant changes in plasma malondialdehyde. The results suggest that uric acid, important antioxidant, is probably oxidized by reactive oxygen species to allantoin. Therefore allantoin may be suitable candidate for a marker of acute oxidative stress. (en)
Title	A monitorong of allantoin, uric acid, and malondialdehyde levels in plasma and erythrocytes after ten minutes of running activity A monitorong of allantoin, uric acid, and malondialdehyde levels in plasma and erythrocytes after ten minutes of running activity (en)
skos:prefLabel	A monitorong of allantoin, uric acid, and malondialdehyde levels in plasma and erythrocytes after ten minutes of running activity A monitorong of allantoin, uric acid, and malondialdehyde levels in plasma and erythrocytes after ten minutes of running activity (en)
skos:notation	RIV/00216275:25310/14:39898292!RIV15-MSM-25310___
http://linked.open...avai/riv/aktivita	I S
http://linked.open...avai/riv/aktivity	I, S
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Kanďár, Roman Štramová, Xenie Drábková, Petra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Pardubice / Fakulta chemicko-technologická
http://linked.open...dnocenehoVysledku	852
http://linked.open...ai/riv/idVysledku	RIV/00216275:25310/14:39898292
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	short-term intense exercise; antioxidants; oxidative stress; uric acid; allantoin (en)
http://linked.open.../riv/klicoveSlovo	allantoin antioxidants uric acid oxidative stress short-term intense exercise
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[3D5B493D6041]
http://linked.open...i/riv/nazevZdroje	Physiological Reasearch
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	63
http://linked.open...iv/tvurceVysledku	Kanďár, Roman Drábková, Petra Štramová, Xenie Křenková, Jana
http://linked.open...ain/vavai/riv/wos	000347371200009
issn	0862-8408
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	25310

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