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| rdf:type
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| Description
| - Background: Heterozygous mutation in the glucocerebrosidase gene lead to an increased risk for and to more severe alpha-synuclein-associated pathology in Parkinson's disease. As both glucocerebrosidase and alpha-synuclein interact with fatty acids, we hypothesized that cerebrospinal fluid fatty acid level are altered in these Parkinson's patients. Methods: Cerebrospinal fluid levels of 13 fatty acids in 8 Parkinson's disease patients with a heterozygous glucocerebrosidase mutation were compared with those of 41 idiopathic Parkinson's disease patients and 30 controls using gas chromatography. Results: Parkinson's disease patients with a heterozygous glucocerebrosidase mutation had lover levels of palmitoleic acid (P= 0.007), oleic (P=0.016), linoleic (P=0.005), arachidonic (P=0.003), eicosapentaeneoic (P=0.003) and docosahexaenoic (P=0.03) acids and lower levels of total fatty acids (P=0.005) compared with both idiopathic Parkinson's disease patients and control subjects. Conclusions: These results suggest that abnormalities of fatty acid metabolism are specifically involved in the pathogenesis of Parkinson's disease associated with a heterozygous glucocerebrosidase mutation
- Background: Heterozygous mutation in the glucocerebrosidase gene lead to an increased risk for and to more severe alpha-synuclein-associated pathology in Parkinson's disease. As both glucocerebrosidase and alpha-synuclein interact with fatty acids, we hypothesized that cerebrospinal fluid fatty acid level are altered in these Parkinson's patients. Methods: Cerebrospinal fluid levels of 13 fatty acids in 8 Parkinson's disease patients with a heterozygous glucocerebrosidase mutation were compared with those of 41 idiopathic Parkinson's disease patients and 30 controls using gas chromatography. Results: Parkinson's disease patients with a heterozygous glucocerebrosidase mutation had lover levels of palmitoleic acid (P= 0.007), oleic (P=0.016), linoleic (P=0.005), arachidonic (P=0.003), eicosapentaeneoic (P=0.003) and docosahexaenoic (P=0.03) acids and lower levels of total fatty acids (P=0.005) compared with both idiopathic Parkinson's disease patients and control subjects. Conclusions: These results suggest that abnormalities of fatty acid metabolism are specifically involved in the pathogenesis of Parkinson's disease associated with a heterozygous glucocerebrosidase mutation (en)
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| Title
| - Cerebrospinal fluid fatty acid in Glucocerebrosidase-Associated Parkinson's Disease
- Cerebrospinal fluid fatty acid in Glucocerebrosidase-Associated Parkinson's Disease (en)
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| skos:prefLabel
| - Cerebrospinal fluid fatty acid in Glucocerebrosidase-Associated Parkinson's Disease
- Cerebrospinal fluid fatty acid in Glucocerebrosidase-Associated Parkinson's Disease (en)
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| skos:notation
| - RIV/00216275:25310/12:39895001!RIV13-MSM-25310___
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| http://linked.open...avai/predkladatel
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216275:25310/12:39895001
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - alpha-synuclein; mutation; Parkinson disease; glucocerebrosidase gene; polyunsaturated fatty acid; cerebrospinal fluid (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Čegan, Alexander
- Baur, Stephanie
- Deutschle, Christian
- Hauser, Ann-Kathrin
- Maetzler, Walter
- Schleicher, Erwin
- Schmid, Stefan
- Srulijes, Karin
- Synofzik, Matthis
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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| is http://linked.open...avai/riv/vysledek
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