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  • A drug delivery system based on physically cross-linked poly vinyl alcohol (PVA)/chitosan blend hydrogels for the release of sparfloxacin antibiotic as a model for drugs was described. Eco-synthesis in current work is based on synthesizing a hydrogel without using chemical crosslinking agents like in the conventional method. In addition all materials are used are non- toxic, safe, non-carcinogenic and can be accepted by the human body without danger. The swelling behavior was tested to be dependent on pH as temperature as well as time and number of freezing thawing cycles. The physical properties of the hydrogels, such as swelling percent, dissolution percent, gel fraction and mechanical properties was assessed. The antimicrobial activity of hydrogels having different compositions was evaluated for both gram positive and gram negative bacteria. Furthermore, the release of antibiotic from hydrogels prepared using the freeze- thawed process was studied.
  • A drug delivery system based on physically cross-linked poly vinyl alcohol (PVA)/chitosan blend hydrogels for the release of sparfloxacin antibiotic as a model for drugs was described. Eco-synthesis in current work is based on synthesizing a hydrogel without using chemical crosslinking agents like in the conventional method. In addition all materials are used are non- toxic, safe, non-carcinogenic and can be accepted by the human body without danger. The swelling behavior was tested to be dependent on pH as temperature as well as time and number of freezing thawing cycles. The physical properties of the hydrogels, such as swelling percent, dissolution percent, gel fraction and mechanical properties was assessed. The antimicrobial activity of hydrogels having different compositions was evaluated for both gram positive and gram negative bacteria. Furthermore, the release of antibiotic from hydrogels prepared using the freeze- thawed process was studied. (en)
Title
  • Eco-Synthesis of PVA/Chitosan Hydrogels for Biomedical Application
  • Eco-Synthesis of PVA/Chitosan Hydrogels for Biomedical Application (en)
skos:prefLabel
  • Eco-Synthesis of PVA/Chitosan Hydrogels for Biomedical Application
  • Eco-Synthesis of PVA/Chitosan Hydrogels for Biomedical Application (en)
skos:notation
  • RIV/00216275:25310/11:39892342!RIV12-MSM-25310___
http://linked.open...avai/predkladatel
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  • 196022
http://linked.open...ai/riv/idVysledku
  • RIV/00216275:25310/11:39892342
http://linked.open...riv/jazykVysledku
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  • Sparfloxacin; Hydrogel; Drug delivery Polyvinyl alkohol; Chitosan (en)
http://linked.open.../riv/klicoveSlovo
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  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [E45EDCB37E38]
http://linked.open...i/riv/nazevZdroje
  • Journal of Polymers and the Environment
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  • 19
http://linked.open...iv/tvurceVysledku
  • Hrdina, Radim
  • Abdel-Lattif, Abdel-Mohsen
  • Aly, A.
  • Hebeish, A.
  • Montaser, A.
http://linked.open...ain/vavai/riv/wos
  • 000297370100022
issn
  • 1566-2543
number of pages
http://bibframe.org/vocab/doi
  • 10.1007/s10924-011-0334-0
http://localhost/t...ganizacniJednotka
  • 25310
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