About: Electrochemical Analysis of DNA: When, How and Why to Use Electroactive Labels and Indicators

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	DNA possesses intrinsic electrochemical activity due to the presence of electrochemically reducible or oxidizable nucleobases and exhibits characteristic, structure-sensitive adsorption/desorption behavior at mercury or amalgam electrodes. Thus, label-free electrochemical DNA sensing is in principle possible, and especially in connection with mercury-based or carbon electrodes the intrinsic DNA electroactivity has been utilized to detect DNA damage. In other applications, such as sequence-specific DNA sensing, typing of single-nucleotide polymorphisms (SNP) etc., utilization of electroactive labels has appeared advantageous. We present several examples of using redox-active or enzymatic DNA tags in the detection of DNA damage, DNA hybridization and minisequencing of the SNP. DNA possesses intrinsic electrochemical activity due to the presence of electrochemically reducible or oxidizable nucleobases and exhibits characteristic, structure-sensitive adsorption/desorption behavior at mercury or amalgam electrodes. Thus, label-free electrochemical DNA sensing is in principle possible, and especially in connection with mercury-based or carbon electrodes the intrinsic DNA electroactivity has been utilized to detect DNA damage. In other applications, such as sequence-specific DNA sensing, typing of single-nucleotide polymorphisms (SNP) etc., utilization of electroactive labels has appeared advantageous. We present several examples of using redox-active or enzymatic DNA tags in the detection of DNA damage, DNA hybridization and minisequencing of the SNP. (en)
Title	Electrochemical Analysis of DNA: When, How and Why to Use Electroactive Labels and Indicators Electrochemical Analysis of DNA: When, How and Why to Use Electroactive Labels and Indicators (en)
skos:prefLabel	Electrochemical Analysis of DNA: When, How and Why to Use Electroactive Labels and Indicators Electrochemical Analysis of DNA: When, How and Why to Use Electroactive Labels and Indicators (en)
skos:notation	RIV/00216275:25310/10:39882506!RIV11-MSM-25310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(LC06035)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Horáková, Petra
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Pardubice / Fakulta chemicko-technologická
http://linked.open...dnocenehoVysledku	256692
http://linked.open...ai/riv/idVysledku	RIV/00216275:25310/10:39882506
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Structure probes; Signal amplification; Enzyme-linked assays; Redox indicators; Electroactive labels; Label-free; DNA electrochemistry (en)
http://linked.open.../riv/klicoveSlovo	DNA electrochemistry Electroactive labels Enzyme-linked assays Label-free Redox indicators Signal amplification Structure probes
http://linked.open...ontrolniKodProRIV	[8511E219B5BD]
http://linked.open...v/mistoKonaniAkce	Jetřichovice
http://linked.open...i/riv/mistoVydani	Ústí nad Labem
http://linked.open...i/riv/nazevZdroje	Sborník přednášek mezinárodní odborné konference XXX. Moderní elektrochemické metody
http://linked.open...in/vavai/riv/obor	CG
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine.
http://linked.open...UplatneniVysledku	2010
http://linked.open...iv/tvurceVysledku	Fojta, Miroslav Havran, Luděk Horáková, Petra Vidláková, Pavlína Špaček, Jan Šimková, Eva Kostečka, Pavel Pivoňková, Hana Vychodilová, Zdenka
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open...ain/vavai/riv/wos	000283050900010
http://linked.open.../riv/zahajeniAkce	2010-05-24 (xsd:date)
number of pages	5 (xsd:int)
http://purl.org/ne...btex#hasPublisher	BEST Servis
https://schema.org/isbn	978-80-254-6710-7
http://localhost/t...ganizacniJednotka	25310
is http://linked.open...avai/riv/vysledek of	Electrochemical Analysis of DNA: When, How and Why to Use Electroactive Labels and Indicators Electrochemical Analysis of DNA: When, How and Why to Use Electroactive Labels and Indicators Electrochemical Analysis of DNA: When, How and Why to Use Electroactive Labels and Indicators

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