About: Prednisolone-alfa-cyclodextrin-star PEG polypseudorotaxanes with controlled drug delivery properties

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The reaction of alpha-amino-omega-methoxypoly(ethylene glycol) [M = 5000] or star alpha-amino-poly(ethylene glycol) [M = 20 000] with hemiesters of prednisolone dicarboxylic acids (succinic, glutaric, adipic, phthalic acid) has been used to prepare the corresponding conjugates. The rate of esterase catalyzed hydrolysis of the conjugates is controlled by the molecular mass of poly(ethylene glycol) and the length of the linker between prednisolone and poly(ethylene glycol) (tau(1/2) similar to 5-0.5 h). The enzymatic hydrolysis proceeds most rapidly at conjugates with linkers derived from adipic and phthalic acids. The synthesized conjugates form polypseudorotaxanes with alpha-cyclodextrin which were characterized by 2D NOESY NMR spectra, powder X-ray diffraction patterns and in one case also by STM microscopy. The reaction of alpha-amino-omega-methoxypoly(ethylene glycol) [M = 5000] or star alpha-amino-poly(ethylene glycol) [M = 20 000] with hemiesters of prednisolone dicarboxylic acids (succinic, glutaric, adipic, phthalic acid) has been used to prepare the corresponding conjugates. The rate of esterase catalyzed hydrolysis of the conjugates is controlled by the molecular mass of poly(ethylene glycol) and the length of the linker between prednisolone and poly(ethylene glycol) (tau(1/2) similar to 5-0.5 h). The enzymatic hydrolysis proceeds most rapidly at conjugates with linkers derived from adipic and phthalic acids. The synthesized conjugates form polypseudorotaxanes with alpha-cyclodextrin which were characterized by 2D NOESY NMR spectra, powder X-ray diffraction patterns and in one case also by STM microscopy. (en)
Title	Prednisolone-alfa-cyclodextrin-star PEG polypseudorotaxanes with controlled drug delivery properties Prednisolone-alfa-cyclodextrin-star PEG polypseudorotaxanes with controlled drug delivery properties (en)
skos:prefLabel	Prednisolone-alfa-cyclodextrin-star PEG polypseudorotaxanes with controlled drug delivery properties Prednisolone-alfa-cyclodextrin-star PEG polypseudorotaxanes with controlled drug delivery properties (en)
skos:notation	RIV/00216275:25310/10:39881308!RIV11-MSM-25310___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021627501), Z(MSM0021627502)
http://linked.open...iv/cisloPeriodika	23
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Ventura, Karel Dvořák, Bohuslav Sedlák, Miloš Beneš, Ludvík Knotek, Petr Bílková, Eliška
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Pardubice / Fakulta chemicko-technologická
http://linked.open...dnocenehoVysledku	281163
http://linked.open...ai/riv/idVysledku	RIV/00216275:25310/10:39881308
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	drug delivery; polypseudorotaxanes; Prednisolone-alpha-cyclodextrin-star PEG (en)
http://linked.open.../riv/klicoveSlovo	polypseudorotaxanes drug delivery Prednisolone-alpha-cyclodextrin-star PEG
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[47732377AB6F]
http://linked.open...i/riv/nazevZdroje	Organic & Biomolecular Chemistry
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Ventura, Karel Dvořák, Bohuslav Knotek, Petr Sedlák, Miloš Beneš, Ludvík Bílková, Eliška
http://linked.open...ain/vavai/riv/wos	000284065000022
http://linked.open...n/vavai/riv/zamer	Aimed preparation of special compounds and materials and investigation of their physical and chemical properties and supramolecular structures Pokročilé analytické a separační metody a jejich aplikace v diagnostice a technologii živých a neživých materiálů
issn	1477-0520
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	25310
is http://linked.open...avai/riv/vysledek of	Prednisolone-alfa-cyclodextrin-star PEG polypseudorotaxanes with controlled drug delivery properties Prednisolone-alfa-cyclodextrin-star PEG polypseudorotaxanes with controlled drug delivery properties Prednisolone-alfa-cyclodextrin-star PEG polypseudorotaxanes with controlled drug delivery properties

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