About: Design and Efficient Synthesis of Amino Acid Derived 2-Substituted Imidazoles by Palladium-Catalyzed Cross-Coupling Reactions

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About: Design and Efficient Synthesis of Amino Acid Derived 2-Substituted Imidazoles by Palladium-Catalyzed Cross-Coupling Reactions Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Optically active imidazole derivatives featuring an aamino acid motive substituted at the 2-position can be prepared in moderate to good yields by Negishi as well as Suzuki?Miyaura cross-couplings as the key synthetic steps. The reaction sequence involves N-protection (ethoxymethylation), whereby both generated regioisomers could be separated by column chromatography, and selective 2-lithiation. Subsequent transmetalation to zinc or an iodine quench affords reactants suitable for Pd-catalyzed Negishi and Suzuki?Miyaura reactions with (hetero)aromatics. Optically active imidazole derivatives featuring an aamino acid motive substituted at the 2-position can be prepared in moderate to good yields by Negishi as well as Suzuki?Miyaura cross-couplings as the key synthetic steps. The reaction sequence involves N-protection (ethoxymethylation), whereby both generated regioisomers could be separated by column chromatography, and selective 2-lithiation. Subsequent transmetalation to zinc or an iodine quench affords reactants suitable for Pd-catalyzed Negishi and Suzuki?Miyaura reactions with (hetero)aromatics. (en)
Title	Design and Efficient Synthesis of Amino Acid Derived 2-Substituted Imidazoles by Palladium-Catalyzed Cross-Coupling Reactions Design and Efficient Synthesis of Amino Acid Derived 2-Substituted Imidazoles by Palladium-Catalyzed Cross-Coupling Reactions (en)
skos:prefLabel	Design and Efficient Synthesis of Amino Acid Derived 2-Substituted Imidazoles by Palladium-Catalyzed Cross-Coupling Reactions Design and Efficient Synthesis of Amino Acid Derived 2-Substituted Imidazoles by Palladium-Catalyzed Cross-Coupling Reactions (en)
skos:notation	RIV/00216275:25310/09:00007558!RIV10-MSM-25310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GP203/07/P013), Z(MSM0021627501)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Bureš, Filip Kulhánek, Jiří Marek, Aleš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Pardubice / Fakulta chemicko-technologická
http://linked.open...dnocenehoVysledku	309636
http://linked.open...ai/riv/idVysledku	RIV/00216275:25310/09:00007558
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	imidazole; cross-coupling; amino acid (en)
http://linked.open.../riv/klicoveSlovo	cross-coupling amino acid imidazole
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[F08108382356]
http://linked.open...i/riv/nazevZdroje	Synthesis
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Nonracemic nitrogen ligands based on imidazole - potencial catalysts of asymmetric reactions.
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	2009
http://linked.open...iv/tvurceVysledku	Bureš, Filip Kulhánek, Jiří Marek, Aleš
http://linked.open...n/vavai/riv/zamer	Aimed preparation of special compounds and materials and investigation of their physical and chemical properties and supramolecular structures
issn	0039-7881
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	25310
is http://linked.open...avai/riv/vysledek of	Design and Efficient Synthesis of Amino Acid Derived 2-Substituted Imidazoles by Palladium-Catalyzed Cross-Coupling Reactions Design and Efficient Synthesis of Amino Acid Derived 2-Substituted Imidazoles by Palladium-Catalyzed Cross-Coupling Reactions Design and Efficient Synthesis of Amino Acid Derived 2-Substituted Imidazoles by Palladium-Catalyzed Cross-Coupling Reactions Design and Efficient Synthesis of Amino Acid Derived 2-Substituted Imidazoles by Palladium-Catalyzed Cross-Coupling Reactions

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