| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - For the synthesis of a structure carrying a label in any of the above-mentioned positions, the corresponding labelled glycine synthon could be prepared from commercially available mono-, di- or tri-labelled glycine. This synthon is further monoalkylated with a suitable electrophile in order to introduce a (protected) side chain, followed by methylation by labelled or non-labelled methyl iodide. An optimization was done in order to increase yields of the complexes and decrease consumption of expensive labelled glycine. Similar optimization of synthesis of a precursor for a-(13C)methyltyrosine gave the ratio of BPB:amino acid:nickel nitrate 1:1.4:1.5. This ratio allows to achieve 87% yield of the complex. The development of more diastereoselective synthons is underway.
- For the synthesis of a structure carrying a label in any of the above-mentioned positions, the corresponding labelled glycine synthon could be prepared from commercially available mono-, di- or tri-labelled glycine. This synthon is further monoalkylated with a suitable electrophile in order to introduce a (protected) side chain, followed by methylation by labelled or non-labelled methyl iodide. An optimization was done in order to increase yields of the complexes and decrease consumption of expensive labelled glycine. Similar optimization of synthesis of a precursor for a-(13C)methyltyrosine gave the ratio of BPB:amino acid:nickel nitrate 1:1.4:1.5. This ratio allows to achieve 87% yield of the complex. The development of more diastereoselective synthons is underway. (en)
- For the synthesis of a structure carrying a label in any of the above-mentioned positions, the corresponding labelled glycine synthon could be prepared from commercially available mono-, di- or tri-labelled glycine. This synthon is further monoalkylated with a suitable electrophile in order to introduce a (protected) side chain, followed by methylation by labelled or non-labelled methyl iodide. An optimization was done in order to increase yields of the complexes and decrease consumption of expensive labelled glycine. Similar optimization of synthesis of a precursor for a-(13C)methyltyrosine gave the ratio of BPB:amino acid:nickel nitrate 1:1.4:1.5. This ratio allows to achieve 87% yield of the complex. The development of more diastereoselective synthons is underway. (cs)
|
| Title
| - New chiral synthons of 13C- or 15N-labeled α-aminoacids.
- New chiral synthons of 13C- or 15N-labeled α-aminoacids. (en)
- New chiral synthons of 13C- or 15N-labeled α-aminoacids. (cs)
|
| skos:prefLabel
| - New chiral synthons of 13C- or 15N-labeled α-aminoacids.
- New chiral synthons of 13C- or 15N-labeled α-aminoacids. (en)
- New chiral synthons of 13C- or 15N-labeled α-aminoacids. (cs)
|
| skos:notation
| - RIV/00216275:25310/07:00006066!RIV08-MSM-25310___
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - Z(MSM0021627501), Z(MSM0021627502)
|
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00216275:25310/07:00006066
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - amino acids; asymetris synthesis; carbon- 13; nitrogen- 15; labelling (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Journal of Labelled Compounds and Radiopharmaceuticals
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Holčapek, Michal
- Weidlich, Tomáš
- Jirásko, Robert
- Lyčka, Antonín
- Nádvorník, Milan
- Popkov, Alexander
- Langer, Vratislav
|
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
| http://localhost/t...ganizacniJednotka
| |
| is http://linked.open...avai/riv/vysledek
of | |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)