About: Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The decrease of TCR diversity with aging has never been studied by direct methods. In this study, we combined high-throughput Illumina sequencing with unique cDNA molecular identifier technology to achieve deep and precisely normalized profiling of TCR beta repertoires in 39 healthy donors aged 6-90 y. We demonstrate that TCR beta diversity per 10(6) T cells decreases roughly linearly with age, with significant reduction already apparent by age 40. The percentage of naive T cells showed a strong correlation with measured TCR diversity and decreased linearly up to age 70. Remarkably, the oldest group (average age 82 y) was characterized by a higher percentage of naive CD4(+) T cells, lower abundance of expanded clones, and increased TCR diversity compared with the previous age group (average age 62 y), suggesting the influence of age selection and association of these three related parameters with longevity. The decrease of TCR diversity with aging has never been studied by direct methods. In this study, we combined high-throughput Illumina sequencing with unique cDNA molecular identifier technology to achieve deep and precisely normalized profiling of TCR beta repertoires in 39 healthy donors aged 6-90 y. We demonstrate that TCR beta diversity per 10(6) T cells decreases roughly linearly with age, with significant reduction already apparent by age 40. The percentage of naive T cells showed a strong correlation with measured TCR diversity and decreased linearly up to age 70. Remarkably, the oldest group (average age 82 y) was characterized by a higher percentage of naive CD4(+) T cells, lower abundance of expanded clones, and increased TCR diversity compared with the previous age group (average age 62 y), suggesting the influence of age selection and association of these three related parameters with longevity. (en)
Title	Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling (en)
skos:prefLabel	Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling (en)
skos:notation	RIV/00216224:14740/14:00079244!RIV15-MSM-14740___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Chudakov, Dmitriy
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	1851
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/14:00079244
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	T-CELL REPERTOIRE; RECEPTOR DIVERSITY; THYMIC INVOLUTION; IMMUNE DEFENSE; OLD PRIMATES; IFN-GAMMA; TNF-ALPHA; RESPONSES; HOMEOSTASIS; GENERATION (en)
http://linked.open.../riv/klicoveSlovo	GENERATION RESPONSES IFN-GAMMA HOMEOSTASIS IMMUNE DEFENSE OLD PRIMATES RECEPTOR DIVERSITY T-CELL REPERTOIRE THYMIC INVOLUTION TNF-ALPHA
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[F90E7AC9094D]
http://linked.open...i/riv/nazevZdroje	Journal of immunology
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	192
http://linked.open...iv/tvurceVysledku	Lukyanov, S. Bolotin, D. A. Chudakov, Dmitriy Shugay, M. Turchaninova, M. A. Bogdanova, E. A. Britanova, O. V. Lebedev, Y.B. Mamedov, I.Z. Merzlyak, E. M. Putintseva, E. V. Staroverov, D. B.
http://linked.open...ain/vavai/riv/wos	000332702700018
issn	0022-1767
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.4049/jimmunol.1302064
http://localhost/t...ganizacniJednotka	14740

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