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  • Background: Cortical changes associated with cognitive decline in Parkinson's disease (PD) are not fully explored and require investigations with established diagnostic classification criteria. Objective: We used MRI source-based morphometry to evaluate specific differences in grey matter volume patterns across 4 groups of subjects: healthy controls (HC), PD with normal cognition (PD-NC), PD with mild cognitive impairment (MCI-PD) and PD with dementia (PDD). Methods: We examined 151 consecutive subjects: 25 HC, 75 PD-NC, 29 MCI-PD, and 22 PDD at an Italian and Czech movement disorder centre. Operational diagnostic criteria were applied to classify MCI-PD and PDD. All structural MRI images were processed together in the Czech centre. The spatial independent component analysis was used to assess group differences of local grey matter volume.
  • Background: Cortical changes associated with cognitive decline in Parkinson's disease (PD) are not fully explored and require investigations with established diagnostic classification criteria. Objective: We used MRI source-based morphometry to evaluate specific differences in grey matter volume patterns across 4 groups of subjects: healthy controls (HC), PD with normal cognition (PD-NC), PD with mild cognitive impairment (MCI-PD) and PD with dementia (PDD). Methods: We examined 151 consecutive subjects: 25 HC, 75 PD-NC, 29 MCI-PD, and 22 PDD at an Italian and Czech movement disorder centre. Operational diagnostic criteria were applied to classify MCI-PD and PDD. All structural MRI images were processed together in the Czech centre. The spatial independent component analysis was used to assess group differences of local grey matter volume. (en)
Title
  • Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients
  • Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients (en)
skos:prefLabel
  • Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients
  • Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients (en)
skos:notation
  • RIV/00216224:14740/14:00078359!RIV15-MSM-14740___
http://linked.open...avai/riv/aktivita
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  • P(ED1.1.00/02.0068)
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  • 1
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  • 18625
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  • RIV/00216224:14740/14:00078359
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  • FRONTAL ASSESSMENT BATTERY; ITALIAN POPULATION-SAMPLE; SOURCE-BASED MORPHOMETRY; DEFAULT MODE NETWORK; DIAGNOSTIC-CRITERIA; ALZHEIMERS-DISEASE; NORMATIVE VALUES; CEREBRAL ATROPHY; LEWY BODIES; DEMENTIA (en)
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  • US - Spojené státy americké
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  • [A09A974744AE]
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  • Plos one
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  • 9
http://linked.open...iv/tvurceVysledku
  • Aarsland, Dag
  • Rektorová, Irena
  • Mareček, Radek
  • Antonini, Angelo
  • Biundo, Roberta
  • Weis, Luca
http://linked.open...ain/vavai/riv/wos
  • 000330244500080
issn
  • 1932-6203
number of pages
http://bibframe.org/vocab/doi
  • 10.1371/journal.pone.0085595
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  • 14740
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