About: Telomere repeat binding proteins are functional components of Arabidopsis telomeres and interact with telomerase

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://onlinelibrary.wiley.com/doi/10.1111/tpj.12428/epdf
Description	Although telomere-binding proteins constitute an essential part of telomeres, in vivo data indicating the existence of a structure similar to mammalian shelterin complex in plants are limited. Partial characterization of a number of candidate proteins has not identified true components of plant shelterin or elucidated their functional mechanisms. Telomere repeat binding (TRB) proteins from Arabidopsis thaliana bind plant telomeric repeats through a Myb domain of the telobox type in vitro, and have been shown to interact with POT1b (Protection of telomeres 1). Here we demonstrate co-localization of TRB1 protein with telomeres in situ using fluorescence microscopy, as well as in vivo interaction using chromatin immunoprecipitation. Classification of the TRB1 protein as a component of plant telomeres is further confirmed by the observation of shortening of telomeres in knockout mutants of the trb1 gene. Moreover, TRB proteins physically interact with plant telomerase catalytic subunits. Although telomere-binding proteins constitute an essential part of telomeres, in vivo data indicating the existence of a structure similar to mammalian shelterin complex in plants are limited. Partial characterization of a number of candidate proteins has not identified true components of plant shelterin or elucidated their functional mechanisms. Telomere repeat binding (TRB) proteins from Arabidopsis thaliana bind plant telomeric repeats through a Myb domain of the telobox type in vitro, and have been shown to interact with POT1b (Protection of telomeres 1). Here we demonstrate co-localization of TRB1 protein with telomeres in situ using fluorescence microscopy, as well as in vivo interaction using chromatin immunoprecipitation. Classification of the TRB1 protein as a component of plant telomeres is further confirmed by the observation of shortening of telomeres in knockout mutants of the trb1 gene. Moreover, TRB proteins physically interact with plant telomerase catalytic subunits. (en)
Title	Telomere repeat binding proteins are functional components of Arabidopsis telomeres and interact with telomerase Telomere repeat binding proteins are functional components of Arabidopsis telomeres and interact with telomerase (en)
skos:prefLabel	Telomere repeat binding proteins are functional components of Arabidopsis telomeres and interact with telomerase Telomere repeat binding proteins are functional components of Arabidopsis telomeres and interact with telomerase (en)
skos:notation	RIV/00216224:14740/14:00073912!RIV15-MSM-14740___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(EE2.3.30.0009), P(GA13-06943S)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Vychodilová, Ivona Schořová, Šárka Dokládal, Ladislav Fajkus, Jiří Majerská, Jana Procházková Schrumpfová, Petra Dvořáčková, Martina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	49695
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/14:00073912
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	telomere protein interaction; telomere repeat binding (TRB); telomere; Arabidopsis thaliana; plant shelterin; telomerase (en)
http://linked.open.../riv/klicoveSlovo	telomerase Arabidopsis thaliana plant shelterin telomere protein interaction telomere repeat binding (TRB) telomere
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[4F4C825BE74A]
http://linked.open...i/riv/nazevZdroje	The Plant Journal
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Strukturní a funkční komponenty rostlinných telomer Central european institute of technology Employment of Newly Graduated Doctors of Science for Scientific Excellence
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	77
http://linked.open...iv/tvurceVysledku	Dokládal, Ladislav Fajkus, Jiří Majerská, Jana Procházková Schrumpfová, Petra Dvořáčková, Martina Schořová, Šárka Vychodilová, Ivona
http://linked.open...ain/vavai/riv/wos	000331848700010
issn	0960-7412
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/tpj.12428
http://localhost/t...ganizacniJednotka	14740

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