About: MiR-190 leads to aggressive phenotype of neuroblastoma through indirect activation of TrkB pathway     Goto   Sponge   NotDistinct   Permalink

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Description
  • Almost one third of all children with advanced stage neuroblastoma (NBL) is incurable. TrkB expressing NBLs frequently have MYCN amplification and are very aggressive and often fatal tumors. Little is known about the mechanisms by which TrkB is regulated. Here, we suggest new mechanism by which TrkB could be regulated. We hypothesize that miR-190 leads to aggressive phenotype of NBL through indirect activation of TrkB pathway, whereas NEUROD1 presents link between miR-190 and TrkB pathway.
  • Almost one third of all children with advanced stage neuroblastoma (NBL) is incurable. TrkB expressing NBLs frequently have MYCN amplification and are very aggressive and often fatal tumors. Little is known about the mechanisms by which TrkB is regulated. Here, we suggest new mechanism by which TrkB could be regulated. We hypothesize that miR-190 leads to aggressive phenotype of NBL through indirect activation of TrkB pathway, whereas NEUROD1 presents link between miR-190 and TrkB pathway. (en)
Title
  • MiR-190 leads to aggressive phenotype of neuroblastoma through indirect activation of TrkB pathway
  • MiR-190 leads to aggressive phenotype of neuroblastoma through indirect activation of TrkB pathway (en)
skos:prefLabel
  • MiR-190 leads to aggressive phenotype of neuroblastoma through indirect activation of TrkB pathway
  • MiR-190 leads to aggressive phenotype of neuroblastoma through indirect activation of TrkB pathway (en)
skos:notation
  • RIV/00216224:14740/13:00067593!RIV14-MSM-14740___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(ED1.1.00/02.0068)
http://linked.open...iv/cisloPeriodika
  • 3
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  • 88519
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14740/13:00067593
http://linked.open...riv/jazykVysledku
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  • miR-190; microRNA; neuroblastoma; TrkB pathway (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [244F59043675]
http://linked.open...i/riv/nazevZdroje
  • Medical Hypotheses
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http://linked.open...vavai/riv/projekt
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http://linked.open...v/svazekPeriodika
  • 80
http://linked.open...iv/tvurceVysledku
  • Slabý, Ondřej
http://linked.open...ain/vavai/riv/wos
  • 000315834400026
issn
  • 0306-9877
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.mehy.2012.11.033
http://localhost/t...ganizacniJednotka
  • 14740
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