About: Off-line MALDI and ICP MS detection of a single record of metallothionein separation

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	It is estimated that one third of all proteins require metals to carry out their functions. Therefore, the analyses of native metal-protein and metal-metabolite complexes by hyphenated techniques that combine separation with a specific detection is of growing importance. A new concept of an off-line multidetection platform for metalloprotein/metallopeptide analysis of fractions collected from a single run of capillary electrophoresis (CE) or liquid chromatography (LC) is presented. The separation record, i.e. fractions collected on a target, are analyzed sequentially with MALDI MS and SALD ICP MS. Thus, a single separation can yield both proteomic and metallomic information. Moreover, the off-line nature of the analysis provides further possibilities, such as laser-induced fluorescence detection or on target digestion. It is estimated that one third of all proteins require metals to carry out their functions. Therefore, the analyses of native metal-protein and metal-metabolite complexes by hyphenated techniques that combine separation with a specific detection is of growing importance. A new concept of an off-line multidetection platform for metalloprotein/metallopeptide analysis of fractions collected from a single run of capillary electrophoresis (CE) or liquid chromatography (LC) is presented. The separation record, i.e. fractions collected on a target, are analyzed sequentially with MALDI MS and SALD ICP MS. Thus, a single separation can yield both proteomic and metallomic information. Moreover, the off-line nature of the analysis provides further possibilities, such as laser-induced fluorescence detection or on target digestion. (en)
Title	Off-line MALDI and ICP MS detection of a single record of metallothionein separation Off-line MALDI and ICP MS detection of a single record of metallothionein separation (en)
skos:prefLabel	Off-line MALDI and ICP MS detection of a single record of metallothionein separation Off-line MALDI and ICP MS detection of a single record of metallothionein separation (en)
skos:notation	RIV/00216224:14740/13:00066028!RIV14-MSM-14740___
http://linked.open...avai/predkladatel	Středoevropský technologický institut
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068), P(GA203/09/1025), P(GAP206/12/0538), S
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Millionová, Radka Tomalová, Iva Preisler, Jan Polanský, Ondřej Foltynová, Pavla
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	93510
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/13:00066028
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mass spectrometry; off-line coupling; separation; metalloproteomics (en)
http://linked.open.../riv/klicoveSlovo	mass spectrometry separation metalloproteomics off-line coupling
http://linked.open...ontrolniKodProRIV	[29AC6B3E0B64]
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Novel front-end strategies for desorption mass spectrometry Central european institute of technology Multidetection platform for microcolumn separation of proteins and peptides
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Preisler, Jan Tomalová, Iva Foltynová, Pavla Polanský, Ondřej Millionová, Radka
http://localhost/t...ganizacniJednotka	14740

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