About: Expression analysis of microRNAs in relation to the chemoradioresistance of glioblastoma

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About: Expression analysis of microRNAs in relation to the chemoradioresistance of glioblastoma Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Glioblastoma multiforme (GBM) is the most frequent primary malignant brain tumor with very poor prognosis. Despite an optimal treatment composed of a maximal surgical resection followed an intense concomitant chemoradiotherapy with temozolomide and adjuvant temozolomide, the median of overall survival remains only 12-15 months from diagnosis. Because of a different response to treatment, it is very important to find new biomarkers that can be used in prediction of a clinical outcome in GBM patients, who underwent chemoradiotherapy. MicroRNAs are highly conserved, small, non-coding RNAs that function as post-transcriptional regulators of gene expression. Therefore, these molecules play key role in pathogenesis of many cancers, including GBM. Glioblastoma multiforme (GBM) is the most frequent primary malignant brain tumor with very poor prognosis. Despite an optimal treatment composed of a maximal surgical resection followed an intense concomitant chemoradiotherapy with temozolomide and adjuvant temozolomide, the median of overall survival remains only 12-15 months from diagnosis. Because of a different response to treatment, it is very important to find new biomarkers that can be used in prediction of a clinical outcome in GBM patients, who underwent chemoradiotherapy. MicroRNAs are highly conserved, small, non-coding RNAs that function as post-transcriptional regulators of gene expression. Therefore, these molecules play key role in pathogenesis of many cancers, including GBM. (en)
Title	Expression analysis of microRNAs in relation to the chemoradioresistance of glioblastoma Expression analysis of microRNAs in relation to the chemoradioresistance of glioblastoma (en)
skos:prefLabel	Expression analysis of microRNAs in relation to the chemoradioresistance of glioblastoma Expression analysis of microRNAs in relation to the chemoradioresistance of glioblastoma (en)
skos:notation	RIV/00216224:14740/13:00065596!RIV14-MZ0-14740___
http://linked.open...avai/predkladatel	Středoevropský technologický institut
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068), P(NT13514)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Kosařová, Zdeňka Slabý, Ondřej Šána, Jiří Bešše, Andrej
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	74343
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/13:00065596
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	microRNA; chemoresistance; radioresistance; glioblastoma multiforme (en)
http://linked.open.../riv/klicoveSlovo	glioblastoma multiforme chemoresistance radioresistance microRNA
http://linked.open...ontrolniKodProRIV	[1AC6274BC793]
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology MicroRNA analysis in glioblastoma stem cells: prediction of therapy response and identification of new therapeutic targets in glioblastoma patients
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Slabý, Ondřej Šána, Jiří Lakomý, Radek Smrčka, Martin Vyzula, Rostislav Bešše, Andrej Kosařová, Zdeňka
http://localhost/t...ganizacniJednotka	14740

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