About: TRAMP Stimulation of Exosome

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: TRAMP Stimulation of Exosome Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/B978-0-12-404740-2.00004-5
Description	In order to control and/or enhance the specificity and activity of nuclear surveillance and degradation, exosomes cooperate with the polyadenylation complex called TRAMP. Two forms of TRAMP operate in budding yeast, TRAMP4 and TRAMP5. They oligoadenylate defective or precursor forms of RNAs and promote trimming or complete degradation by exosomes. TRAMPs target a wide variety of nuclear transcripts. The known substrates include the noncoding RNAs originating from pervasive transcription from diverse parts of the yeast genome. Although TRAMP and exosomes can be triggered to a subset of their targets via the RNA-binding complex Nrd1, it is still not completely understood how TRAMP recognizes other aberrant RNAs. The existence of TRAMP-like complexes in other organisms indicates the importance of nuclear surveillance for general cell biology. In this chapter, we review the current understanding of TRAMP function and substrate repertoire. In order to control and/or enhance the specificity and activity of nuclear surveillance and degradation, exosomes cooperate with the polyadenylation complex called TRAMP. Two forms of TRAMP operate in budding yeast, TRAMP4 and TRAMP5. They oligoadenylate defective or precursor forms of RNAs and promote trimming or complete degradation by exosomes. TRAMPs target a wide variety of nuclear transcripts. The known substrates include the noncoding RNAs originating from pervasive transcription from diverse parts of the yeast genome. Although TRAMP and exosomes can be triggered to a subset of their targets via the RNA-binding complex Nrd1, it is still not completely understood how TRAMP recognizes other aberrant RNAs. The existence of TRAMP-like complexes in other organisms indicates the importance of nuclear surveillance for general cell biology. In this chapter, we review the current understanding of TRAMP function and substrate repertoire. (en)
Title	TRAMP Stimulation of Exosome TRAMP Stimulation of Exosome (en)
skos:prefLabel	TRAMP Stimulation of Exosome TRAMP Stimulation of Exosome (en)
skos:notation	RIV/00216224:14740/12:00065939!RIV14-MSM-14740___
http://linked.open...avai/predkladatel	Středoevropský technologický institut
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068), P(GAP305/11/1095)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Vaňáčová, Štěpánka Holub, Peter
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	174836
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/12:00065939
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	TRAMP; Noncanonical polyadenylation; RNA degradation; RNA surveillance; Trf4; Zinc knuckle proteins; Air1; Mtr4; Noncoding RNAs (en)
http://linked.open.../riv/klicoveSlovo	Air1 Mtr4 Noncanonical polyadenylation Noncoding RNAs RNA degradation RNA surveillance TRAMP Trf4 Zinc knuckle proteins
http://linked.open...ontrolniKodProRIV	[5AA65BCBE51C]
http://linked.open...i/riv/mistoVydani	Burlington
http://linked.open...vEdiceCisloSvazku	%22Vol. 31%22; Part A
http://linked.open...i/riv/nazevZdroje	The Enzymes: Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis, Part A
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...v/pocetStranKnihy	265 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Functional and biochemical characterization of Dis3L2, the third mammalian homolog of the key yeast exosome nuclease Dis3p Central european institute of technology
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Vaňáčová, Štěpánka Holub, Peter
number of pages	19 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/B978-0-12-404740-2.00004-5
http://purl.org/ne...btex#hasPublisher	Elsevier
https://schema.org/isbn	9780124047402
http://localhost/t...ganizacniJednotka	14740

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 22 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software