About: Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://pubs.acs.org/doi/abs/10.1021/nn303508c?mi=qryllt&af=R&pageSize=20&searchText=ATP
Description	During passive endocytosis, nanosized particles are initially encapsulated by a membrane separating it from the cytosol. Yet, in many applications the nanoparticles need to be in direct contact with the cytosol in order to be active. We report a simulation study that elucidates the physical mechanisms by which such nanoparticles can shed their bilayer coating. We find that nanoparticle release can be readily achieved by a pH-induced lowering of the attraction between nanoparticle and membrane only if the nanoparticle is either very small or nonspherical. Interestingly, we find that in the case of large spherical nanoparticles, the reduction of attraction needs to be accompanied by exerting an additional tension on the membrane (e.g., via nanoparticle expansion) to achieve release. We expect these findings will contribute to the rational design of drug delivery strategies via nanoparticles. During passive endocytosis, nanosized particles are initially encapsulated by a membrane separating it from the cytosol. Yet, in many applications the nanoparticles need to be in direct contact with the cytosol in order to be active. We report a simulation study that elucidates the physical mechanisms by which such nanoparticles can shed their bilayer coating. We find that nanoparticle release can be readily achieved by a pH-induced lowering of the attraction between nanoparticle and membrane only if the nanoparticle is either very small or nonspherical. Interestingly, we find that in the case of large spherical nanoparticles, the reduction of attraction needs to be accompanied by exerting an additional tension on the membrane (e.g., via nanoparticle expansion) to achieve release. We expect these findings will contribute to the rational design of drug delivery strategies via nanoparticles. (en)
Title	Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction (en)
skos:prefLabel	Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction (en)
skos:notation	RIV/00216224:14740/12:00064625!RIV13-MSM-14740___
http://linked.open...avai/predkladatel	Středoevropský technologický institut
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Vácha, Robert
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	142742
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/12:00064625
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cytosol release; late endosome; ligand-receptor interaction; phospholipid membrane; nanoparticle shape; molecular dynamics (en)
http://linked.open.../riv/klicoveSlovo	cytosol release late endosome nanoparticle shape phospholipid membrane ligand-receptor interaction molecular dynamics
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[16ED1FCB90D2]
http://linked.open...i/riv/nazevZdroje	ACS Nano
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	6
http://linked.open...iv/tvurceVysledku	Frenkel, Daan Vácha, Robert Martinez-Veracoechea, Francisco J.
http://linked.open...ain/vavai/riv/wos	000312563600020
issn	1936-0851
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1021/nn303508c
http://localhost/t...ganizacniJednotka	14740
is http://linked.open...avai/riv/vysledek of	Intracellular Release of Endocytosed Nanoparticles Upon a Change of Ligand-Receptor Interaction

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