About: Synergism of the Two Myb Domains of Tay1 Protein Results in High Affinity Binding to Telomeres*

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About: Synergism of the Two Myb Domains of Tay1 Protein Results in High Affinity Binding to Telomeres* Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ncbi.nlm.nih.gov/pubmed/22815473
Description	Double-stranded regions of the telomeres are recognized by proteins containing Myb-like domains conferring specificity toward telomeric repeats. Although biochemical and structural studies revealed basic molecular principles involved in DNA binding, relatively little is known about evolutionary pathways leading to various types of Myb domain-containing proteins in divergent species of eukaryotes. Recently we identified a novel type of telomere-binding protein YlTay1p from the yeast Yarrowia lipolytica containing two Myb domains (Myb1, Myb2) very similar to the Myb domain of mammalian TRF1 and TRF2. In this study we prepared mutant versions of YlTay1p lacking Myb1, Myb2, or both Myb domains and found that YlTay1p carrying either Myb domain exhibits preferential affinity to both Y. lipolytica (GGGTTAGTCA)n and human (TTAGGG)n telomeric sequences. Double-stranded regions of the telomeres are recognized by proteins containing Myb-like domains conferring specificity toward telomeric repeats. Although biochemical and structural studies revealed basic molecular principles involved in DNA binding, relatively little is known about evolutionary pathways leading to various types of Myb domain-containing proteins in divergent species of eukaryotes. Recently we identified a novel type of telomere-binding protein YlTay1p from the yeast Yarrowia lipolytica containing two Myb domains (Myb1, Myb2) very similar to the Myb domain of mammalian TRF1 and TRF2. In this study we prepared mutant versions of YlTay1p lacking Myb1, Myb2, or both Myb domains and found that YlTay1p carrying either Myb domain exhibits preferential affinity to both Y. lipolytica (GGGTTAGTCA)n and human (TTAGGG)n telomeric sequences. (en)
Title	Synergism of the Two Myb Domains of Tay1 Protein Results in High Affinity Binding to Telomeres* Synergism of the Two Myb Domains of Tay1 Protein Results in High Affinity Binding to Telomeres* (en)
skos:prefLabel	Synergism of the Two Myb Domains of Tay1 Protein Results in High Affinity Binding to Telomeres* Synergism of the Two Myb Domains of Tay1 Protein Results in High Affinity Binding to Telomeres* (en)
skos:notation	RIV/00216224:14740/12:00057815!RIV13-GA0-14740___
http://linked.open...avai/predkladatel	Středoevropský technologický institut
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068), P(GAP205/12/0550)
http://linked.open...iv/cisloPeriodika	38
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Pavloušková, Jana Wimmerová, Michaela Fajkus, Jiří Hofr, Ctirad Nečasová, Ivona
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	172860
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/12:00057815
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA-BINDING; ARABIDOPSIS-THALIANA; COMPLEX; TRF1; IDENTIFICATION; RECOGNITION; SPECIFICITY; PROTECTION; EVOLUTION; GENOME (en)
http://linked.open.../riv/klicoveSlovo	PROTECTION DNA-BINDING IDENTIFICATION ARABIDOPSIS-THALIANA COMPLEX EVOLUTION RECOGNITION SPECIFICITY GENOME TRF1
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[5F165ED11D66]
http://linked.open...i/riv/nazevZdroje	The Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology Dynamics of shelterin complex assembly
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	287
http://linked.open...iv/tvurceVysledku	Wimmerová, Michaela Fajkus, Jiří Hofr, Ctirad Nečasová, Ivona Griffith, Jack D. Nosek, Jozef Pavloušková, Jana Sepsiova, Regina Simonicova, Lucia Tomaska, Lubomir Visacka, Katarina Willcox, Smaranda
http://linked.open...ain/vavai/riv/wos	000309059400057
issn	0021-9258
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1074/jbc.M112.385591
http://localhost/t...ganizacniJednotka	14740
is http://linked.open...avai/riv/vysledek of	Synergism of the Two Myb Domains of Tay1 Protein Results in High Affinity Binding to Telomeres*

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