About: Burkholderia cenocepacia lectin A binding to heptoses from the bacterial lipopolysaccharide

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About: Burkholderia cenocepacia lectin A binding to heptoses from the bacterial lipopolysaccharide Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://glycob.oxfordjournals.org/content/22/10/1387.abstract
Description	Bacteria from the Burkholderia cepacia complex (Bcc) cause highly contagious pneumonia among cystic fibrosis (CF) patients. Among them, Burkholderia cenocepacia is one of the most dangerous in the Bcc and is the most frequent cause of morbidity and mortality in CF patients. Indeed, it is responsible of “cepacia syndrome”, a deadly exacerbation of infection, that is the main cause of poor outcomes in lung transplantation. Burkholderia cenocepacia produces several soluble lectins with specificity for fucosylated and mannosylated glycoconjugates. These lectins are present on the bacterial cell surface and it has been proposed that they bind to lipopolysaccharide epitopes. In this work, we report on the interaction of one B. cenocepacia lectin, BC2L-A, with heptose and other manno configured sugar residues. Bacteria from the Burkholderia cepacia complex (Bcc) cause highly contagious pneumonia among cystic fibrosis (CF) patients. Among them, Burkholderia cenocepacia is one of the most dangerous in the Bcc and is the most frequent cause of morbidity and mortality in CF patients. Indeed, it is responsible of “cepacia syndrome”, a deadly exacerbation of infection, that is the main cause of poor outcomes in lung transplantation. Burkholderia cenocepacia produces several soluble lectins with specificity for fucosylated and mannosylated glycoconjugates. These lectins are present on the bacterial cell surface and it has been proposed that they bind to lipopolysaccharide epitopes. In this work, we report on the interaction of one B. cenocepacia lectin, BC2L-A, with heptose and other manno configured sugar residues. (en)
Title	Burkholderia cenocepacia lectin A binding to heptoses from the bacterial lipopolysaccharide Burkholderia cenocepacia lectin A binding to heptoses from the bacterial lipopolysaccharide (en)
skos:prefLabel	Burkholderia cenocepacia lectin A binding to heptoses from the bacterial lipopolysaccharide Burkholderia cenocepacia lectin A binding to heptoses from the bacterial lipopolysaccharide (en)
skos:notation	RIV/00216224:14740/12:00057548!RIV13-GA0-14740___
http://linked.open...avai/predkladatel	Středoevropský technologický institut
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068), P(GA303/09/1168), P(GD301/09/H004)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Adamová, Lenka Malinovská, Lenka Wimmerová, Michaela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	125705
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/12:00057548
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	bacterial lectin; heptose; lipopolysaccharide; NMR; titration microcalorimetry (en)
http://linked.open.../riv/klicoveSlovo	lipopolysaccharide titration microcalorimetry heptose NMR bacterial lectin
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[EC07CB59A612]
http://linked.open...i/riv/nazevZdroje	Glycobiology
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology Lectins from human pathogens - structure, function, engineering Molecular and structural biology of selected antitumor drugs. From mechanistic studies to chemotherapy of tumors
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	22
http://linked.open...iv/tvurceVysledku	Adamová, Lenka Cioci, Gianluca Imberty, Anne Kosma, Paul Malinovská, Lenka Wimmerová, Michaela Lameignere, Emilie Marchetti, Roberta Molinaro, Antonio Silipo, Alba Stanetty, Christian de Castro, Cristina
http://linked.open...ain/vavai/riv/wos	000308011800011
issn	0959-6658
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1093/glycob/cws105
http://localhost/t...ganizacniJednotka	14740
is http://linked.open...avai/riv/vysledek of	Burkholderia cenocepacia lectin A binding to heptoses from the bacterial lipopolysaccharide

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