About: Real-time visualization of protein empty space with varying parameters

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Exploration of empty space inside protein structures is playing a crucial role in protein engineering and drug design. Such empty space inside protein can be utilized for design of protein mutations. The importance of empty space is also based on its ability to accept a small ligand molecule which can react with the protein. The product of such reaction can form a basis of new medications. Many algorithms enabling computation of these empty spaces, often marked as voids, have been published and their results were evaluated by protein engineers to confirm their chemical relevance. However, not each void of the protein can be considered as a target point of ligand binding. Thus the following examination and assessment of all voids has to be performed. In this phase the visual representation of voids is very valuable and substantially decreases time of this evaluation phase. In this paper, we introduce a novel algorithm for visualization and further evaluation of voids in real-time. Exploration of empty space inside protein structures is playing a crucial role in protein engineering and drug design. Such empty space inside protein can be utilized for design of protein mutations. The importance of empty space is also based on its ability to accept a small ligand molecule which can react with the protein. The product of such reaction can form a basis of new medications. Many algorithms enabling computation of these empty spaces, often marked as voids, have been published and their results were evaluated by protein engineers to confirm their chemical relevance. However, not each void of the protein can be considered as a target point of ligand binding. Thus the following examination and assessment of all voids has to be performed. In this phase the visual representation of voids is very valuable and substantially decreases time of this evaluation phase. In this paper, we introduce a novel algorithm for visualization and further evaluation of voids in real-time. (en)
Title	Real-time visualization of protein empty space with varying parameters Real-time visualization of protein empty space with varying parameters (en)
skos:prefLabel	Real-time visualization of protein empty space with varying parameters Real-time visualization of protein empty space with varying parameters (en)
skos:notation	RIV/00216224:14330/13:00065959!RIV14-MSM-14330___
http://linked.open...avai/predkladatel	Fakulta informatiky
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(GAP202/10/1435), P(LG13010), S
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Šustr, Vilém Kozlíková, Barbora Strnad, Ondřej Sochor, Jiří
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Fakulta informatiky
http://linked.open...dnocenehoVysledku	101654
http://linked.open...ai/riv/idVysledku	RIV/00216224:14330/13:00065959
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	protein; empty space; void; visualization; real-time; cavity (en)
http://linked.open.../riv/klicoveSlovo	cavity protein visualization empty space real-time void
http://linked.open...ontrolniKodProRIV	[8F09C2DC4E4E]
http://linked.open...v/mistoKonaniAkce	Lisbon, Portugal
http://linked.open...i/riv/mistoVydani	Lisbon/Portugal
http://linked.open...i/riv/nazevZdroje	Proceedings of Biotechno
http://linked.open...in/vavai/riv/obor	IN
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Czech Republic representation in the European Research Consortium for Informatics and Mathematics (ERCIM) Analysis and Visualization of Protein Structures
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Kozlíková, Barbora Sochor, Jiří Strnad, Ondřej Šustr, Vilém
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2013-03-22 (xsd:date)
number of pages	6 (xsd:int)
http://purl.org/ne...btex#hasPublisher	IARIA XPS Press
https://schema.org/isbn	9781612082608
http://localhost/t...ganizacniJednotka	14330

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