About: Transcription density map as a new tool for evaluation of various expression profiles: Ex vivo differentiation of CD34+ cells     Goto   Sponge   NotDistinct   Permalink

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  • Microarrays technology is a very powerful tool for monitoring gene expression. In our experiments with CD34+ differentiation assays, we used Transcription density map (TDM) as a new tool for evaluation of expression patterns in enriched populations of different cell lineages. Hematopoietic stem cells (enriched in fraction of CD34+ cells) have the ability to regenerate hematopoiesis. This potential is clinically used in transplanting bone marrow or peripheral blood stem cells. TDM is an improved transcription map. Genes are mapped on chromosomes according to their offset in basepairs (instead of sequential ordering used by traditional transcription maps (TMs)). TDM clearly and exactly shows the differences in expression patterns of evaluated populations. We can see the differences in expression level between individual genes and also between gene families or chromosome regions.
  • Microarrays technology is a very powerful tool for monitoring gene expression. In our experiments with CD34+ differentiation assays, we used Transcription density map (TDM) as a new tool for evaluation of expression patterns in enriched populations of different cell lineages. Hematopoietic stem cells (enriched in fraction of CD34+ cells) have the ability to regenerate hematopoiesis. This potential is clinically used in transplanting bone marrow or peripheral blood stem cells. TDM is an improved transcription map. Genes are mapped on chromosomes according to their offset in basepairs (instead of sequential ordering used by traditional transcription maps (TMs)). TDM clearly and exactly shows the differences in expression patterns of evaluated populations. We can see the differences in expression level between individual genes and also between gene families or chromosome regions. (en)
Title
  • Transcription density map as a new tool for evaluation of various expression profiles: Ex vivo differentiation of CD34+ cells
  • Transcription density map as a new tool for evaluation of various expression profiles: Ex vivo differentiation of CD34+ cells (en)
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  • Transcription density map as a new tool for evaluation of various expression profiles: Ex vivo differentiation of CD34+ cells
  • Transcription density map as a new tool for evaluation of various expression profiles: Ex vivo differentiation of CD34+ cells (en)
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  • RIV/00216224:14330/06:00040704!RIV11-MZ0-14330___
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  • RIV/00216224:14330/06:00040704
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  • microarrays; gene expression (en)
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  • Kozubek, Michal
  • Klabusay, Martin
  • Krontorád Koutná, Irena
  • Tesařová, Lenka
  • Hrabčáková, Viera
  • Krontorád, Petr
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  • 14330
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