About: Liquid Chromatography - Tandem Mass Spectrometry Method for Determination of Homocysteine in Rat Plasma: Application to the Study of a Rat Model for Tauopathies     Goto   Sponge   NotDistinct   Permalink

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  • Hyperhomocysteinemia is a common occurrence in many neurodegenerative diseases, including tauopathies. We developed and validated a simple and sensitive liquid chromatography-tandem mass spectrometry method for the analysis of homocysteine (Hcy) in rat plasma. The method showed excellent linearity with regression coefficients higher than 0.99. The accuracy was in the range of 93-98%. The inter-day precision (n=5 days), expressed as % relative standard deviation, was in the range 3-8%. The process was validated in compliance with the EMA quideline. Using this method, we analyzed plasma samples from two transgenic lines of the rat model for tauopathies.
  • Hyperhomocysteinemia is a common occurrence in many neurodegenerative diseases, including tauopathies. We developed and validated a simple and sensitive liquid chromatography-tandem mass spectrometry method for the analysis of homocysteine (Hcy) in rat plasma. The method showed excellent linearity with regression coefficients higher than 0.99. The accuracy was in the range of 93-98%. The inter-day precision (n=5 days), expressed as % relative standard deviation, was in the range 3-8%. The process was validated in compliance with the EMA quideline. Using this method, we analyzed plasma samples from two transgenic lines of the rat model for tauopathies. (en)
Title
  • Liquid Chromatography - Tandem Mass Spectrometry Method for Determination of Homocysteine in Rat Plasma: Application to the Study of a Rat Model for Tauopathies
  • Liquid Chromatography - Tandem Mass Spectrometry Method for Determination of Homocysteine in Rat Plasma: Application to the Study of a Rat Model for Tauopathies (en)
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  • Liquid Chromatography - Tandem Mass Spectrometry Method for Determination of Homocysteine in Rat Plasma: Application to the Study of a Rat Model for Tauopathies
  • Liquid Chromatography - Tandem Mass Spectrometry Method for Determination of Homocysteine in Rat Plasma: Application to the Study of a Rat Model for Tauopathies (en)
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  • RIV/00216224:14310/14:00077625!RIV15-MSM-14310___
http://linked.open...avai/riv/aktivita
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  • N
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  • december
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http://linked.open...aciTvurceVysledku
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  • 26322
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/14:00077625
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  • liquid chromatography; mass spectrometry; rat plasma; homocysteine; tauopathies (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • SK - Slovenská republika
http://linked.open...ontrolniKodProRIV
  • [A96770D354DE]
http://linked.open...i/riv/nazevZdroje
  • Journal of Chromatographic Science
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  • Neuveden
http://linked.open...iv/tvurceVysledku
  • Novák, Michal
  • Švihlová, Katarína
  • Kovac, Andrej
  • Michalicova, Alena
issn
  • 0021-9665
number of pages
http://localhost/t...ganizacniJednotka
  • 14310
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